openmolecules.org Forum: Cheminformatics

Search
Help
Members
Register
Login
Home

Home » DataWarrior » Cheminformatics » LE, LLE & LELP

Show: Today's Messages :: Polls :: Message Navigator

LE, LLE & LELP [message #1496]

Mon, 07 February 2022 13:51

Christophe
Messages: 34
Registered: January 2022

Member

Hello everyone,

If I only have Kd data instead of IC50 for my compounds. Does it make any sense to calculate normalized Ligand efficiencies (LE, LLE and/or LELP) based on Kd rather than on a true activity ?
It happens (very/too often) that a low Kd does not correlate with high activity, but in my particular case, Kd can be easily measured contrary to IC50.
Many thanks

Report message to a moderator

Previous Topic:	3-D structures vs descriptors
Next Topic:	Importing compounds with assay data from Pubchem into Datawarrior

Goto Forum:

-=] Back to Top [=-

[ Syndicate this forum (XML) ] [

] [

]

Current Time: Fri Feb 06 09:19:30 CET 2026

Total time taken to generate the page: 0.00433 seconds