<i>N</i> -Amination of Indoles on Pilot-Plant Scale via Simultaneous and Proportional Metering of Reagents
| Type | Journal Article |
|---|---|
| Author | Franz J. Weiberth |
| Author | Reda G. Hanna |
| Author | George E. Lee |
| Author | Yvonne Polverine |
| Author | Joseph T. Klein |
| URL | http://pubs.acs.org/doi/abs/10.1021/op100330h |
| Volume | 15 |
| Issue | 3 |
| Pages | 704-709 |
| Publication | Organic Process Research & Development |
| ISSN | 1083-6160, 1520-586X |
| Date | 2011-05-20 |
| Journal Abbr | Org. Process Res. Dev. |
| DOI | 10.1021/op100330h |
| Accessed | 6/20/2014, 9:50:59 PM |
| Library Catalog | CrossRef |
| Language | en |
| Abstract | The N-amination of indoles on large scale, utilizing a portable Coriolismass flow metering and pumping system that provides precise dispensing of two reagent streams simultaneously and proportionally, is described. |
| Date Added | 12/24/2015, 2:54:43 PM |
| Modified | 6/6/2019, 8:00:39 AM |
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Extracted Annotations (6/6/2019, 7:53:59 AM)
"A scaleable process for N-amination of indoles was described. A dispensing system consisting of portable Coriolis massflow meters and a dual pump was assembled and demonstrated to provide simultaneous and proportional dispensing of two reagent streams in a precise manner, essential for achieving high amination conversions. The versatility and portability of the equipment provided additional value because the equipment was used in the preparation of three different N-aminoindoles in pilot plants of varying capabilities at three different sites without the need for extensive equipment or facility upgrades to accommodate the specific dispensing requirements." (Weiberth 2011:707)
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