macroName=Show All Columns defCriterion= columnList=Status Supplier Supplier ID Notes on Structure Literature IC50 uM (In vitro assay) IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB Fu (%) Donna's Favorites Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Amount Lot Date Prepared Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) CRL Tom20 Loss, w O/A uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Status Supplier Supplier ID Notes on Structure Literature IC50 uM (In vitro assay) IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Amount Lot Date Prepared Comments Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) Solubility (uM) CRL Tom20 Loss, w O/A uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Comments CP Caco A to B CP Efflux Ratio CP HLM t1/2 (min) CP MLM t1/2 (min) CP RLM t/12 (min) CP Solubility (uM) CRL Tom20 Loss, w O/A uMol Donna's Favorites Dundee % Activity at 1 uM (avg in vitro MS assay) Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee Average IC50 Dundee IC50 s.d. ID Literature IC50 uM (In vitro assay) Lot Amount Lot Amount Units Lot Date Prepared Lot Notebook Page Lot Number Lot Purity Notes on Structure Viva Efflux Ratio Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva Solubility uMol columnDefMode=list viewName=Table defCriterion= columnList=Comments CP Caco A to B CP Efflux Ratio CP HLM t1/2 (min) CP MLM t1/2 (min) CP RLM t/12 (min) CP Solubility (uM) CRL Tom20 Loss, w O/A uMol Donna's Favorites Dundee % Activity at 1 uM (avg in vitro MS assay) Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee Average IC50 Dundee IC50 s.d. hPPB (%) hPPB Fu (%) ID Literature IC50 uM (In vitro assay) Lot Amount Lot Amount Units Lot Date Prepared Lot Notebook Page Lot Number Lot Purity mPPB (%) Notes on Structure PHN Ave IC50 PHN Efflux Ratio PHN HLM with NADPH in vitro Clint (ul/min/mg protein) PHN HLM with NADPH T1/2 (min) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH T1/2 (min) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH T1/2 (min) PHN Solubility (uM) rPPB (%) Status Structure Structure of SMILES [2D-Coordinates] Structure of SMILES [FragFp] Supplier Supplier ID Viva Efflux Ratio Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva Solubility uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB (%) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Comments Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN Ave IC50 Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) mPPB % rPPB (%) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) Viva Efflux Ratio Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva Solubility uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB (%) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Comments Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) mPPB % rPPB (%) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) CRL Tom20 Loss, w O/A uMol Viva Efflux Ratio Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva Solubility uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Status Notes on Structure Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Solubility (uM) hPPB (%) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Comments Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN Ave IC50 Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) mPPB % rPPB (%) CRL Tom20 Loss, w O/A uMol Viva Efflux Ratio Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva Solubility uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB (%) hPPB Fu (%) Donna's Favorites Comments Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN Ave IC50 Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) mPPB % rPPB (%) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) CRL Tom20 Loss, w O/A uMol Viva Efflux Ratio Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva Solubility uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB (%) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Comments Solubility (_M) PHN Ave IC50 Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN HLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) mPPB % rPPB (%) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) CRL Tom20 Loss, w O/A uMol Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Solubility uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Supplier ID Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN Ave IC50 Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) CRL Tom20 Loss, w O/A uMol Viva Efflux Ratio Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva Solubility uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Supplier ID Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Caco A to B Efflux Ratio Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB (%) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Comments Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN Ave IC50 PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) mPPB % rPPB (%) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) CRL Tom20 Loss, w O/A uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Supplier ID Notes on Structure Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB (%) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Comments PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN Ave IC50 Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) mPPB % rPPB (%) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) CRL Tom20 Loss, w O/A uMol Viva Efflux Ratio Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP columnDefMode=list macroName=Show All Columns defCriterion= columnList=Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB (%) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Comments Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN Ave IC50 Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) mPPB % rPPB (%) PHN HLM with NADPH T1/2 (min) PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) CRL Tom20 Loss, w O/A uMol Viva Efflux Ratio Viva h Parent Remaining at 5 h Viva h PPB (%) Viva m Parent Remaining at 5 h Viva m PPB (%) Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva r Parent Remaining at 5 h Viva r PPB (%) Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva Solubility uMol columnDefMode=list macroName=Show All Columns defCriterion= columnList=Comments CP Caco A to B CP Efflux Ratio CP HLM t1/2 (min) CP MLM t1/2 (min) CP RLM t/12 (min) CP Solubility (uM) CRL Tom20 Loss, w O/A uMol Donna's Favorites Dundee % Activity at 1 uM (avg in vitro MS assay) Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee Average IC50 Dundee IC50 s.d. hPPB (%) hPPB Fu (%) Literature IC50 uM (In vitro assay) Lot Amount Lot Amount Units Lot Date Prepared Lot Notebook Page Lot Number Lot Purity mPPB (%) Notes on Structure PHN Ave IC50 PHN Efflux Ratio PHN HLM with NADPH in vitro Clint (ul/min/mg protein) PHN HLM with NADPH T1/2 (min) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH T1/2 (min) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN RLM with NADPH T1/2 (min) PHN Solubility (uM) rPPB (%) Status columnDefMode=list FragFp idcoordinates2D ID Structure of SMILES Status Supplier Supplier ID Notes on Structure Literature IC50 uM (In vitro assay) Average IC50 IC50 s.d. Dundee % Activity at 10uM (avg in vitro MS assay) Dundee % Activity at 1 uM (avg in vitro MS assay) Caco A to B Efflux Ratio Solubility (uM) Hu t1/2 (min) Ra t/12 (min) Mu t1/2 (min) hPPB (%) hPPB Fu (%) Donna's Favorites Lot Number Lot Amount Lot Amount Units Lot Purity Lot Notebook Page Lot Date Prepared Comments Solubility (_M) PHN Efflux Ratio PHN Recovery (%)AP-BL PHN Recovery (%)BL-AP PHN Ave IC50 Dundee % Inhibition at 10uM (avg in vitro MS assay) Dundee % Inhibition at 1 uM (avg in vitro MS assay) PHN Papp (A-B) (10-6, cm/s) PHN Papp (B-A) (10-6, cm/s) PHN HLM with NADPH T1/2 (min) PHN HLM with NADPH in vitro Clint (ul/min/mg protein) mPPB % PHN RLM with NADPH T1/2 (min) PHN MLM with NADPH T1/2 (min) PHN RLM with NADPH in vitro CLint (uL/min/mg protein) PHN MLM with NADPH in vitro CLint (uL/min/mg protein) rPPB (%) CRL Tom20 Loss, uMol Viva Solubility uMol Viva Papp (A-B) (10-6, cm/s) Viva Papp (B-A) (10-6, cm/s) Viva Efflux Ratio Viva Recovery (%)AP-BL Viva Recovery (%)BL-AP Viva hPPB (%) Viva h Parent Remaining at 5 h Viva rPPB (%) Viva r Parent Remaining at 5 h Viva mPPB (%) Viva m Parent Remaining at 5 h Chiral purity Chiral Desc. 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99 E06645-189P1 2020-08-13 NaN =v:xyixpqfyUzylXQHuWc9UhWU0g7nrK5mg2llN2OpWDA7eba5pC8XWVEeFcE1V4X0Zt24D@!K04W8F0 !BrKuAO|`Bu{wHg\a]o\bBu}^}r@KH`m^BrKwWoXKHo\c~O|bBuxKHo_y@u{wH`m^BuxK~PLb}?`@WOX`B?e}W?I_|rKwHoQ\}?i?HoP NI17-0285 enY\JL@IMBnAHfe`H``HYdLbbbTbQrdTUbRRbabRRqXTaIqi``VJjfjjf@@@HBAJ@@ Pharmaron PH-VIN-0131 Single stereoisomer 1 0.0077 g 99 E06639-085A1 2020-08-06 0.111 NaN :UvzntztNiwWqAiUwPlXQHuW89MdYC0g7nq54mg3GlN2OpWD96V_a4pC8VWVEeFcB1V0X0at24D8!K04WcF0 !B_X`Bm{]}b@Jw@oz@bGtEH@f?_~Fw@hc|b@Jw@hc}b@JH__y?b@JH?_z@b@Jw@oz@bOw~@K]}b@K~_{_|mpJH_Xc}mww~_xa} NI17-0284 ej^RBD@LG@bhDDa`@`fPrRPjJQQUEJZIJJZIIKFssyFGEZ`j`rfjf@@@HBCJ@@ Pharmaron PH-VIN-0111 Single stereoisomer 1 0.0408 g 99 E06639-025A1 2020-08-06 0.019 NaN :UvzvtzvRiyWqQyUwPtXQHuf89rdYC0g7nr54mg3GlN2OpYD96X_a6pC@VWVEeFcB1V0X0at24D8!K04WcF0 !BQ\Hzw]uEpck]Noy\pdVIOADcHv{]NlHzpck]_}tzpdWBNlIE?bOBNlIE?esBNmtz?esBQ_y\wXWBnoxcwSk]NlIEpdW]Q_xcpdT NI17-0283 efURBD@LOHjhDLi`@bfPrRPjJQQHjiSQIQSQIIXrNJNVA@xhdkTETEeMUL@@@U@PEP@ Pharmaron PH-VIN-0110 Single stereoisomer 1 0.0439 g 99 E06639-024A1 2020-08-06 0.166 NaN ;vzntztsiwWqAiUwPlXQHuW89MdWC2gMnq54mg2GlO6OpWDA7V_aKrC8VdcEuFcC1V0XVZt24DB04K04WcF0 !Bo\bBu}^}rHKW`gx@JNw~PC?~o]_W`d`Br@K~PM^}rEwH`lb}?c?H`lb}?dCH`m^B?dCHoWx@EsuH`gz_UwrW_Dc]RCvWwWz_rKt NI17-0282 efQ\JD@LHjhDMLi`@bfPrRPjJQQHjiSQIQSQIIXvA@xhdkTETGEMUL@@@PDAT@@ Pharmaron PH-VIN-0137 Single stereoisomer 1 0.0435 g 99 E06639-031P1 2020-07-30 0.100 NaN ;vzntztsiwWqAiUwPlXQHuW89MdWC2gMnq54mg2GlO6OpWDA7V_aKrC8VdcEuFcC1V0XVZt24DB04K04WcF0 !BwR`BEq\}J@IW`hD@rJw~HE?~OY_Wpbb|jGs~HI_}RAth`jc]_a?H@b`}_l@h@a\B_l@hwWy@y}wH`gx_E?sg?L`}rCwgWWx_JMt NI17-0281 efQRJD@LGHjhDMLi`@bfPrRPjJQQHjiSQIQSQIIXvA@xhdkTETGEMUL@@@PDAT@@ Pharmaron PH-VIN-0134 Single stereoisomer 1 0.0261 g 99 E06645-180A1 2020-07-30 0.162 NaN =ntztuiw_qAizw8lXQHuWc9MdWj0g7nX54mg2GlN2OpW6A7V_a_pC8VWVEeFcE1V0V04d2ZD8!KF4W8F0 !BbGu^_s@Bm?vH?Xa}?X`Bm{_}bOrH@k\BbGu_APT`?g~H@`T`bGw~@H`Bm?s~@Ha}?`Bw?X`B?g~w@k_|bGvH?[]}?g~H?P NI17-0280 eb^\JL@IMLnA@dn`H``HqdLbbbTbQrbbLrTTtRRVKBgbStHJLDBqUSUTp@@ADDDT@@ Pharmaron PH-VIN-0130 Single stereoisomer 1 0.0305 g 99 E06639-012A1 2020-07-30 0.054 NaN =n:tyixpqAezrclXAHcWc9MpVhVg7l2J5mg2llF0OoW696BbaZpB80WV5eFcB1V4V04d2Ze@!G!W8F0 !BORbBEq_]J@IW`hD@rJtOcSD`JKrh_HoDGzYHGRbBjMu~G|`BJCu~pB`BEpI~pB`}_dCgw\bB_a|W?N_|rCwHO^]]_a|hwP NI17-0279 eb^\JD@LOLhDCHn`@cFPrRPjJIIJiSQIQSQIIXzNFVOP`hkTEAQSUS@@@DPHTQJ@@ Pharmaron PH-VIN-0141 Single stereoisomer 1 0.0373 g 99 E06645-179E1 2020-07-23 0.020 NaN =n:tyixpqAezrclXAHcWc9MpVhVg7l2J5mg2llF0OoW696BbaZpB80WV5eFcB1V4V04d2Ze@!G!W8F0 !BORbBEq_]J@IW`hD@rJtOcSD`JKrh_HoDGzYHGRbBjMu~G|`BJCu~pB`BEpI~pBc]_dCgw\bB_a|W?N\BrMwHO^]]_a|hOP NI17-0278 eb^\JD@LOLhDCHn`@cFPrRPjJIIJiSQIQSQIIXzNFVOP`hkTEAQSUS@@@DPHTIJ@@ Pharmaron PH-VIN-0138 Single stereoisomer 1 0.0363 g 99 E06645-170A1 2020-07-23 0.016 NaN :UvzvtzvRiyWqQyUwPtXQHuf89rdWE0g7nr54mg2GlN2OpYDA7X_a7pC@VWVEeFcE1V0X0Zt24D8!K04W8F0 !BjCw~GvcBEsuhOV`}OZaBey\}ZLJhPi]BjCu?uVeP{q[~gvaB~PBhO_z`ZDHWPoz`jCw~XA_]ZLK~Gq]BEtIhOV`}E}w~Gz`} NI17-0277 ejY\BL@IMBnAHa`H``HIdLbbbTbQrdTUfRbfbRRqXT|rBr~Qaq``VJjfji`@@BJBAJ@@ Pharmaron PH-VIN-0129 Single stereoisomer 1 0.0300 g 98 E06645-200A1 2020-07-23 0.140 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!WcF0 !BwRbBEq_]J@IW`hD@rJw~HE?~OY\h_Jb|?bAHGR`BjMu~G|`BJCu~pB`BEpI~pB`}_dCgw\`B_a|W@n\BrCwHO^_]_a|hOP NI17-0276 ebV\BD@LOLhDHn`@cFPrRPjJQIDiSQIQSQIIXfNOP`hkTEPYSUS@@@DA@e@@ Pharmaron PH-VIN-0135 Single stereoisomer 1 0.0546 g 99 E06639-032A1 2020-07-16 0.045973557 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!WcF0 !BwRbBEq\}JHIW`hD@rJw~HE?~OY\hoJa|?bAHGRbBjMu~G|`BJMu~pBbBExI~pBc]_dCgw\bB_a|W@n_|rMwHO^]]_a|hOP NI17-0275 ebVRBD@LKOLhDHn`@cFPrRPjJQIDiSQIQSQIIXfNOP`hkTEPYSUS@@@DA@e@@ Pharmaron PH-VIN-0132 Single stereoisomer 1 0.0388 g 98 E06639-016A1 2020-07-16 0.89 0.0756736 0.89 :UvzntztNiwWqAiUwPlXQHuW89MdWE0g7nq54mg2GlN2OpWDA7V_a5pC8VWVEeFcE1V0X0Zt24D8!K04W8F0 !B?`Bw@h`Bmww~@Ox@@k^w_WvHb@JH@g?~bGu??ovw?Xc~_x`BbGw~@H`BmpK~@Ha}mww~@H`B?g~w@k\BbGvH__x@?g~H_P NI17-0274 ebV\BL@IMLnAHn`H``HqdLbbbTbQrdT\RTTtRRVKBctHJLDBqUTuTp@@A@PIP@ Pharmaron PH-VIN-0128 Single stereoisomer 1 0.0399 g 99 E06645-199A1 2020-07-16 0.81 0.022529102 0.81 =v;xzxzyvzUzTnfvuud@jUhWxug:r5_mhXGlQ6OpWiA7ebaSrCDqveEyFsC3V4XVZt2ZDB04KV4W8F0 !B_T`BMs]}R@Hw@oz@bCt[F?z@FvPw@dc|rOpw@`V`bMtw_T`B?k|w@da}Mwtw__z?R@Hw@da}?hAH@c\B?hAH__x@uwvH@o{_MpHw@hb}RKwW__{_RGt NI17-0273 ec_RFD@LHdmhDMAeo`@cVPrRPjJQQHkYQIJHsIQSQIIXvA]KLrbjkTETEEUTuUL@@@QAAM@@ Pharmaron PH-VIN-0119 Single stereoisomer 1 0.0336 g 99 E06639-015P1 2020-07-09 49.06 46.27 75.01 77.30 0.063509523 0.34 15.94 49.06 =v;xzxzyvzUzTnvvQuf@jUhWxigUvr54nhXGlv6OpfiA7X_aMrC8kvsEuFsC3V0XVZt3ZDB04pm4W8F0 !B_T`BMs]}R@Hw@oz@bCtw__z@FvPw@dc|rOpw@c]}bMv_AWj`R@H[YAmdRGuzhOz?R@IH__z@R@Hw@oz@RGw~@M]}b@K~ws\BMpJHoTb}uww~wta} NI17-0272 emWRFD@LGLehDMNag`@aVPrRPjJQQHkSIIZFIJJZIIKFpJkjdWfUZ`j`hjjfjf@@@H``f`@ Pharmaron PH-VIN-0118 Single stereoisomer 1 0.05 g 99 E06645-172A1 2020-07-09 0.124994738 NaN =v;xzxzyvvUrTnffucd@jU_VxsgjxM4_mhXGlH0OoWi96@baBpBDLnX5iFsB3V4X0Zt2Z@8!GV0W8F0 !B_T`BMs]}R@Hw@oz@bCt[F?z@FvQH?Lc|MpJHwS]}R@K~os\BRGtw_S]}?k}H@c\BRGw~`D`BMpK~`Da}?`CW_X`B?m|w@c\BbKuHo]]}?m}H_P NI17-0271 ee[RJD@LO@ihDFak`@bVPrRPjJQIGIQIJHsIQSQIIXfNUCD|lbkTEPQUUMUS@@@DPP]P@ Pharmaron PH-VIN-0117 Single stereoisomer 1 0.0079 g 99 E06645-190P1 2020-07-09 39.89 12.15 69.51 69.21 0.027503802 1.16 14.05 39.89 :Uvzv:xS:nqAvUrQO3APdb89M_kC9u3xT64mjHIWmcSiYD1H4ai4xD84YV5cHdBAk0XFZt90m#G!W8F0 !B_X`Bm{]}b@Jw@kx@bEu_APT`WwjH?Dc|bMvH@ha}?g~H@ha}ilC~_xQT`Dz[fr@E?Hc|mpC~@O{|mpC~ NI17-0270 eoh\BD@LGDhD@n`@azPrRPjJQJyJZJIRqIXrrihzyZ`j@ijjX@HbBI@@ Pharmaron PH-VIN-0145 Single stereoisomer 1 0.0406 g 99 E06645-191A1 2020-07-02 >10 NaN :Uvzv:xS:nqAvUrQO3APdb89M_kC9u3xT64mjHIWmcSiYD1H4ai4xD84YV5cHdBAk0XFZt90m#G!W8F0 !B_X`Bm{]}b@Jw@kx@bEu_APT`WwjH?Dc|bMvH@ha}?g~H@ha}ilC~_xQT`Dz[fr@E?Hc|mpC~@O{|mpC~ NI17-0269 eoh\BD@LGDhD@n`@azPrRPjJQJyJZJIRqIXrrihzyZ`j@ijjX@HbBJ@@ Pharmaron PH-VIN-0122 Single stereoisomer 1 0.033 g 99 E06645-167A1 2020-07-02 9.51 3.126 9.51 =v;xzxzyvvUrTnvfQcf@jU_VxggEtM44nhXGlm0Oofi962_a6pB8Fnk5eFsB3V0X0Zt3Z@8!lX0W8F0 !B_T`BMs]}R@Hw@oz@bCtw__z@FvQH?Lc|MpJHwY|E^jAH@amdFvQH_Wj`?k}H@da}?hAH@c\B?hAH__x@uwvH@o{_MpHw@hb}RKwW__{_RGt NI17-0268 eiSRJD@LKHahDJfc`@`VPrRPjJQIGQIIZFIJJZIIKDqsJkEfgeZ`jBJjiji`@@BHHNh@@ Pharmaron PH-VIN-0116 Single stereoisomer 0.019985 1 0.041 g 99 E06645-178D1 2020-07-02 1.72 53.51 63.42 0.044 4.39 7.53 NaN :UvzntztNiwWqAeUoPWXAHcW89MWVB0Z7lJ44mg2GlF0toWD9a0_a4KB!WV5eFVg1V0X0Zt24@8!G!W8F0 !Bo\bBu}^}rHKW`ky@RIwWoXKHo\aH@l`BREwH`lb}?c?H`lb}?dCH`m^B?dCH@lb}?`@WOX`B?e}W?I_|RKwHoQ\}?e?HoP NI17-0267 ebV\JL@LGDhD@fn`@`hHqdLddJbdRnRfbRdTLRRVIectHJJuATASURp@@A@PQP@ Pharmaron PH-VIN-0123 Single stereoisomer 1 0.0201 g 99 E06645-163A1 2020-06-24 >10 NaN =vIn Mitobridge Patent 0.018395 90.38186672 1 0.037 g 99 E06645-176A1 2020-06-24 Highly Unstable in mouse and rat plasma 50.00 11.89342856 79.46930132 77.79757778 0.006 0.011 1.089110162 12.95325391 N.A. N.A. 50 =vIn Mitobridge Patent 0.01589 1 0.0237 g 99 E06645-166A1 2020-06-24 6.74 0.051 6.74 :UvzvtzvRiyWqQuUoPO2AIcf89MWVC0s3lT44ng2KWJ0CafDG20Za6pDe4WV5cFcB9V0X0Zt802#G!W8F0 !BOX`Bey\}b@JW@kz@bCv~@I_|esvH?Hc|bKvH?H`}oe~H?Hb}o`BH@kvHohBHoSh`[sjH?Ky_bCvHo[y_bCt NI17-0265 e`X\BD@LGDhD@f`@czPrRPjJQJyJZIJJZEKFVWOKTEPEMUMP@PPQP@ Viva V124312-000-001 2 0.08 g 98.9 V2528-014-P2 2020-08-13 13:49:26 100.0 NaN =vtzxyjw_qAvzoQlXAPcbc9MWkh9g7pM64HiHIlF8OwYD9L2_iZxBN0WV1eHdB1k02FZt3ZP801G!W8FF !B_X`Bm{]}b@Jw@oz@bGvw__x@mpJH?H`BmpJH?[]}b@JH__y?b@JH?_z@b@K~_{\B?hBH?_x@mwvH@oy?m?rw@ha}bOvw__y?bGt NI17-0264 efQRJD@LF@bhDKDi`@bfPrRPjJQIGKJZJISSQIIXfN@xhdkTEPQTuUL@@@PDFT@@ Pharmaron PH-VIN-0105 Single stereoisomer 1 0.012 g 99 E06645-157A1 2020-06-18 3.069 NaN =vtzxyjw_qA:wQlXQPubc9MdlhAgMrr74miHIlODOxYDAMX_ipzC8VdcEuHdC1k0XkZt3ZTB05KF4W8F0 !B_X`Bm{]}b@Jw@oz@bGvw__x@mpJw@hc|b@Jw@k]}bOvw_X`BbGw~_x`BbOw~@H`B?g~w@oz@bOw~@K]}b@K~_{_|mpJH_Xc}mww~_xa} NI17-0263 eaU\FD@LDfhDMGBm`@cfPrRPjJQQHk[JZJISSQIIXvAHtdlkTETEESUTp@@A@PUP@ Pharmaron PH-VIN-0103 Single stereoisomer 1 0.0498 g 95 E06645-162A1 2020-06-18 4.865 NaN =ntztNiwWqAeUo8lXAHcW89MWVh0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!Y8G0 !B_X`Bm{]}b@Jw@oz@bGvw_Xc|b@Jw@hc}b@JH__y?b@JH?_x@b@Jw@oz@bOw~@K]}b@K~_{_|mpJH_Xc}mww~_xa} NI17-0262 edR\JD@LKHhDMOJ`@bFPrRPjIIHiSQIQSQIIXjFG_O@kTDDTuTp@@A@PAP@ Pharmaron PH-VIN-0101 Single stereoisomer 0.01558 1 0.0374 g 99 E06645-145C1 2020-06-18 0.100 NaN =ntztsiwWqAiUw8lXQHuW89MdWh2gMnX54mg2GlO6OpW6A7V_aKrC8VdcEuFcC1V0VV4d24DB04KF0Y8G0 !B_X`Bm{]}b@Jw@oz@bGvw_[\BbOrH@k\BmwvH?X`BbGw~_x`BbOw~@H`BmpK~`Hc}?`Bw_X`B?g~w?K\BbGvH?[]}?g~H_P NI17-0261 ebV\FD@LOLhDICHn`@cFPrRPjIQIJiSQIQSQIIXzNOP`hkTEAQSUS@@@DA@e@@ Pharmaron PH-VIN-0102 Single stereoisomer 0.03271 1 0.0247 g 97 E06645-152A1 2020-06-11 0.135366153 NaN =ntztsiw_qAiUw8lXQHuW89MdWh2gMnX54mg2GlO6OpW6A7V_aKrC8VdcEuFcC1V0VV4d2ZDB04KF0W8F0 !B_X`Bm{]}b@Jw@oz@bGvw_[\BbOrH@k\B?`BH?[]}b@JH__y?b@JH?_x@b@Jw@oz@bOw~@K]}b@K~_{_|mpJH_Xc}mww~_xa} NI17-0260 ej^\FD@L@bhDICDa`@`fPrRPjIQIK[JZIJJZIIKGQsyFGEZ`hJJfjf@@@HBCJ@@ Pharmaron PH-VIN-0100 Single stereoisomer 0.029375 1 0.0282 g 98 E06645-151A1 2020-06-11 0.09856004 NaN :UvzntztNiwWqAiUwPlXQHuW89MdWC0g7nq54mg2GlF0OpWDA7V_a5pC8VWWCfFcB1V2a0Zt24E8!G14W8F0 !BGWAbCp|]\FHwoAz@jBMwO[x@MwqpXgAbo`BhHwAbjBMaowAbjBL^`GAbeup^`J`cGh@OGWAbX[~WWI]\jBNhHp|]X[~hHp NI17-0259 ebV\BL@LOLhDHn`@brPqdLddJbdRlJTtRTTtRRVIcctHJJuATDTuTp@@A@PIP@ Pharmaron PH-VIN-0089 Single stereoisomer 0.01642 98.95346732 1 0.0467 g 99 E06645-148C1 2020-06-11 Highy Unstable in mouse plasma*15.74 % Stability at 6 hr 0.45 0.037839248 N.A. 92.8* 0.45 =v:xzyzpqfyUzglYQHulc9UhdSXgUnXK5mg2llO6OpW6A7cbaKrC8kdcEuFcC1V4VW4d24DD04K04W8F0 !BqZBrKx}]DBiODiY@^HlWxyD@A{S`ra@jSqIODiY@^HnQ@NCJ^HniO~CJ^HnVpNCJA{RVPGbKedCoU^@jjS|Gm@^t^Hmxbv}UjS}xbp NI17-0258 enU\FD@LDfhDEHbe`@afPrRPjJJIIKGJZIJJZIIKDpIrJDgFeZ`jBhjZjX@@@bBBj@@ Pharmaron PH-VIN-0099 Single stereoisomer 0.01942 93.49 1 0.0268 g 99 E06645-150A1 2020-06-04 *57.27% Stability at 6 hr 1.97 31.48062212 72.78056648 73.89501596 0.058023724 0.404745885 12.74165226 93.36* 89.45 1.97 =ntztuiw_qAizwPlXQHuWc9MdWh2gMnr54mg2GlO6OpWDA7X_aprC8VdcEuFcC1V0XVZt2ZDB05KF4W8F0 !BI\@r[|?]hLhoxiX@NDoWdyrhasRGuJCJhLjORiX@NDnWDzCJnLni_zAJnLnV@JAJa}RV@KcKe`B_uZCJjW}GMD\tNDlxRy?UjW~xrp NI17-0257 enY\FD@LDfhDMGBe`@afPrRPjJQQHk[JZIJJZIIKFpJDgFeZ`j`hjZjX@@@`HJh@@ Pharmaron PH-VIN-0098 Single stereoisomer 0.04802 97.63 1 0.0237 g 99 E06645-149A1 2020-06-04 *11.91 % Stability at 6 hr 6.36 4.86893093 57.55733218 66.30722635 0.3145747660.121 1.956853947 9.527786707 96.41* 94.27 4.29 11.41 16.81 1.47 114.13 129.82 98.46 113.89 96.84 55.04 96.72 21.45 5.325 :UvzntztNiwWqAiUw8lXQHuW89MdWC0g7nX54mg2GlF0OpW6A7V_a5pC8VWWCfFcB1V2Z04d24E8!G14W8F0 !B[S@RSt}mlIIWwJz@zNLOWSBRlII^@NcclIKhxyF?lIKhxzz@lIKg{Jz@zNNn`H~mlIJQo~_ly~shx~ccczvQo~cc NI17-0256 edR\BL@LKHhDOJ`@cRPadLddJbRtJTtRTTtRRVJaawspJuAAEMUL@@@PD@T@@ Pharmaron PH-VIN-0088 Single stereoisomer 0.053155 1 0.041 g 99 E06645-142A1 2020-06-04 0.481172855 NaN =vtzxyjw_qAvzoQlXAPcbc9MWkh9g7pM64miHIlF8OwYD9L2_iZxB80WV5eHdB1k0XFZt3ZP801G!W8F0 !B_X`Bm{]}b@Jw@oz@bGvw__x@mpJH?H`BmpJH?[]}b@JH__y?b@JH?_x@b@K~_{\B?hBH?_x@mwvH@oy?m?rw@ha}bOvw__y?bGt NI17-0255 efQ\JD@L@bhDKDi`@bfPrRPjJQIGKJZJISSQIIXfN@xhdkTEPQTuUL@@@PDFT@@ Pharmaron PH-VIN-0104 Single stereoisomer 1 0.0451 g 99 E06645-144A1 2020-05-28 3.940109861 NaN :UvzntztNiwWqAiUwPlXQHuW89MdWC0g7nq54mg2GlN2OpWDA7V_a5pC8VWVEeFcC1V0X0Zt24D8!K04W8F0 !Bhrb\Uu^cjIsOTfD@lAwgdsD@s}KOtbb\jIrpGZb\lAt^_zb\lAua@Jb\cvIa@K@]XPBWhzb\Gg~OXh}blAvpGY^cGg~pGP NI17-0254 ebV\BL@LOLhDHn`@cRPqdLddJbdTSrTtRTTtRRVMcctHJJuAU@TuTp@@A@PIP@ Pharmaron PH-VIN-0087 Single stereoisomer 0.022935 98.69639066 1 0.0419 g 99 E06645-137A1 2020-05-28 Highly Unstable in Mouse Plasma*7.16% Stablitity at 6 hours 1.08 0.035568872 N.A. 89.5* 1.08 :UvzntztNiwWqAiUw8lXQHuW89MdWC0g7nX54mg2GlN2OpW6A7V_a5pC8VWVEeFcC1V0V04d24D8!K!W8F0 !Bw_CB}?_]|LIw@mx@rDNw@w^B|LKpplaC|LKHP|E?|LKHP}x@|LKWOMx@rDO^@O_]|LKA_}\|ussHP|aC}}wA_|aC NI17-0253 edR\BL@LKHhDOJ`@bRPadLddJbTQrTtRTTtRRVNaawspJuAPEMUL@@@PD@T@@ Pharmaron PH-VIN-0086 Single stereoisomer 0.046895 1 0.0356 g 99 E06645-136A1 2020-05-28 0.301850107 NaN =ntztPiwWqAezoPlXAHcW89MWVh0g7lM44Hg2GlF0OoWD962_aZpBN0WV1eFcB1V020Zt24@8!G!Y8GF !BoRbBUu^}JHIW`dD@rFwsAIWO}@Ph_Ja|jmAHgRbBjCw~W|bBJKw~pBbBUxK~pBb}?dBWO\bB?e}W@i\BrKwHoY\}?e|hoP NI17-0252 ebVRJD@LFOLhDKHn`@cFPrRPjJQIDiSQIQSQIIXfNOP`hkTEPQSUS@@@DA@e@@ Pharmaron PH-VIN-0097 Single stereoisomer 0.05047 *90.7 1 0.0267 g 99 E06645-128A1 2020-05-21 *86.4 %Stability at 6hr**67.8 %Stability at 6 hr***38.0 %Stability at 6 hr 265.80 34.02 79.66 80.68 0.059457418 0.46 15.71 388.76 3.57 ***87.1 194.59 150.99 7.12 9.18 **78.8 74.90 89.15 120.13 85.54 68.20 87.02 44.89 170.35 =ntztuiw_qAezoPlXAHcWc9rWVh0g7lM44Hg2GlF0OoWD962_aZpBN0WV1eFcB1V020Zt2Z@801G!W8FF !BGWAbCp|]\FJWWFz@jLO_fYg@yQ~pXgAbf\BhHwAbjBMaowAbjBL^`GAbeup^`J`cG`Aw{[AbXS~WgA^\jBNhHw_mXS~hHp NI17-0251 eb^RJD@LFOLhDKHn`@cFPrRPjJQIDiSQIQSQIIXrVFNOP`hkTEPQSUS@@@E@PIP@ Pharmaron PH-VIN-0096 Single stereoisomer 0.031275 90.8 1 0.0338 g 99 E06645-129A1 2020-05-21 *55.6 %Stability at 6 hr 10.37 17.32 84.51 84.44 0.05469589 0.88 15.20 221.8046479 6.248741913 *90.0 79.66730783 75.83623924 17.39734953 18.27622274 87.8 72.48 2.70 17.98 6.66 93.70 103.28 90.85 101.32 92.23 84.63 91.58 57.58 41.425 [vsixpyQeUpPpXjHgd89M_VhVg7lL44HgXGlF0OoW7960_a4pBN0WV1eFcBWV#Zd2Z@8!G!W8FF !BCUArKr|MTGHgSGZ@fELoCYArTGHgSIcSKpuP\b|M|[|gSE`s|[}P\e`s}hAP\b]L}hAXL?X@SpvP\gD?ItsGSI`sfCMOCWD?VCL NI17-0250 efQRJD@LFGJhDMLi`@bfPrRPjIIKIRJsQIQSQIIXjF@xhdkTDDUUMUL@@@PDAT@@ Pharmaron PH-VIN-0095 Single stereoisomer 0.1752 1 0.0365 g 97 E06645-127A1 2020-05-21 0.917867316 NaN =ntztuiw_qAezoPlXAHcWc9MWVh0g7lM44Hg2GlF0OoWD962_aZpBN0WV1eFcB1V020Zt2Z@801G!W8FF !BCY@rs||MTCKg[OX@FILOkRz@E~rPLe@rYvpXTt|mTCJXT{D?TCJXT?X@TCKGSOX@fEOv@D|MTCJqOr]LqtrXTyaSSpvqOyaS NI17-0249 ej^RJD@LF@bhDKDa`@`fPrRPjJQIGKJZIJJZIIKDqsyFGEZ`jBJfjf@@@HBCJ@@ Pharmaron PH-VIN-0094 Single stereoisomer 0.051275 1 0.082 g 98 E06645-126A1 2020-05-21 0.052610297 NaN =ntztPiwWqAezoPlXAHcW89MWVh0g7lM44mg2GlF0OoWD962_aZpB80WV5eFcB1V0X0Zt24@8!G!Y8G0 !B_T`BMs]}jMpw@bF@\NtK~EVo]O`hWJc\Ji@H[T`BJKw~Oxc|RGw~`D`BMpK~`Da}?`CW_X`B?c|w?M_|RGuH_U]}?c}H_P NI17-0248 ebV\JD@LOLhDKHn`@cFPrRPjJQIDiSQIQSQIIXfNOP`hkTEPQSUS@@@DA@e@@ Pharmaron PH-VIN-0093 Single stereoisomer 0.033155 93.85451432 1 0.0511 g 99 E06645-115A1 2020-05-14 Highly Unstable in Mouse plasma47.21% Stability at 6 hr 91.11 13.3379671 87.02237378 70.44865619 0.021 1.333252827 17.78288234 135.70 10.21 N.A. 86.9* 54.29 3.07 15.30 4.98 89.26 100.20 72.7 =ntztuiw_qAezoPlXAHcWc9rWVh0g7lM44mg2GlF0OoWD962_aZpB80WV5eFcB1V0X0Zt2Z@801G!W8F0 !Bprc\Uu_CJMswHlF@|At_iZU`v]?HwBc\iVCpgRc\|Eu^orc\|Eta`Bc\}rHa`OA]HP@WP|c\gc?wHg\b|IwpgQ]Cgc?pWP NI17-0247 eb^\JD@LOLhDKHn`@cFPrRPjJQIDiSQIQSQIIXrVFNOP`hkTEPQSUS@@@E@PIP@ Pharmaron PH-VIN-0092 Single stereoisomer 0.01315 1 0.0263 g 99 E06645-117A1 2020-05-14 1.90 0.044 1.9 [vsixpyQeUpPpXjHgd89M_VhVg7lL44mgXGlF0OoW7960_a4pB80WV5eFcBWV0V0Zd2Z@8!G!W8F0 !BsSCRst?MLMIgkHz@zNOOsUCRtMIgkN`SS|wPtd?Mt[}gkAbSt[|ptabSsh@ptf^lsh@Xdtx@C|wPtmD?YzrgkAbSFILOs]D?FIL NI17-0246 efQ\JD@LGJhDMLi`@bfPrRPjIIKIRJsQIQSQIIXjF@xhdkTDDUUMUL@@@PDAT@@ Pharmaron PH-VIN-0091 Single stereoisomer 0.126575 1 0.0526 g 99 E06645-124A1 2020-05-14 1.109 NaN =v;xzxzyQvUr8nffPcd@AM_VhcgEx245Hh2GlH0OoWa960ba4pBNFnV1eFsB3V4!4d2Z@820GV0W8FF !BARAzWu|EhGh{eGj`iAl_iRAzhGh{eJP[Cuv`^bE?U}rdfp}]CutEgzAzU}rdfwj`hGj[iGj`iImzhI|EhGhEgyndfvRdfzR[gpTEgzR[ NI17-0245 ea]ZJD@LIKGNhDBfm`@cfPrRPjIIKIQIJHsIQSQIIXjFYMHtdlkTDDUUSUTp@@ADDET@@ Pharmaron PH-VIN-0085 Single stereoisomer 0.08893 92.7 1 0.0369 g 99 E06645-122A1 2020-05-14 *4.9 %Stability at 6 hr**13.3 %Stability at 6 hr 158.36 11.07 92.57 97.61 0.264 1.16 12.84 4.03 343.54 **83.7 *40.7 73.26 3.35 14.90 4.45 94.28 101.91 92.50 117.14 19.79 1.44 82.40 16.28 115.81 =v;xzxzqQvUr8nfAPcf@AM_VhcgEt244Hh2Glm0OoYa960_a6pBNFlV1eFsB3V#4d3Z@820GX0W8FF !BG[Abcx|]\NKWoNz@jJOwO[Cb\NKWoJbc}st~@GCbu{sWOFbcO`CaowCbZJOn`GCbEysn`Fbc{h@O{WCbx[~WgA^\ZJMhhp?mx[}hhp NI17-0244 enUZJD@LIMOFhDLbe`@afPrRPjIIKQIIZFIJJZIIKEPrKJDgFeZ``bjjZjX@@@bBBj@@ Pharmaron PH-VIN-0084 Single stereoisomer 0.2073 1 0.0277 g 99 E06645-121A1 2020-04-30 0.745 NaN =ntztNiwWqAeUo8lXAHcW89MWVh0g7l244Hg2GlF0OoW6960_a4pBN0WV1eFcB1V#4d24@820G!Y8GF !BoPbB]w^}BHKwPkx@R@Lw`pbBBHKwPd`CBHIH@xE?BHIH@{x@BHHw_Kx@R@N~@G^}BHJA_s]|MwqH@t`C]{vA_t`C NI17-0243 edRRJD@LIKHhDMOJ`@bFPrRPjIIHiSQIQSQIIXjFG_O@kTDDTuTp@@A@PAP@ Pharmaron PH-VIN-0083 Single stereoisomer 0.05341 1 0.0359 g 99 E06645-120A1 2020-04-30 0.249 NaN =v;xzxzyQvUr8nffPcd@AM_VhcgEx245Hh2GlH0OoWa960ba4pBNFnV1eFsB3V4!4d2Z@8!GV0W8FF !BuQCJ[v?UDLhgSEY@n@loCQCJDLhgSK`KUrLPray?CzJxBu\cUrLiOqCJCzJxBuY@DLjG]EY@n@mVPF?UDLhiOx]tawRxB{`K[}TiO{`K NI17-0242 ea]ZJD@LFKGNhDBfm`@cfPrRPjIIKIQIJHsIQSQIIXjFYMHtdlkTDDUUSUTp@@ADDET@@ Pharmaron PH-VIN-0081 Single stereoisomer 0.081175 1 0.0514 g 99 E06645-118A1 2020-04-30 0.142 NaN =v;xzxzqQvUr8nfAPcf@AM_VhcgEt244Hh2Glm0OoYa960_a6pBNFlV1eFsB3V#4d3Z@8!GX0W8FF !Bs]CRs|?MtMJWgLz@FINOG]CRtMJWgAbScqwn@MCReyrWGAbS{`@qo}CRFIMN`MCRYzqN`AbSShCOs]CRt[}gkF^lFILXd|?Mt[|Xdp NI17-0241 enUZJD@LFMOFhDLbe`@afPrRPjIIKQIIZFIJJZIIKEPrKJDgFeZ``bjjZjX@@@bBBj@@ Pharmaron PH-VIN-0080 Single stereoisomer 0.4263 1 0.0228 g 99 E06645-123A1 2020-04-30 0.607 NaN =ntztuiw_qAezoPlXAHcWc9MWVh0g7lM44mg2GlF0OoWD962_aZpB80WV5eFcB1V0X0Zt2Z@801G!W8F0 !BkSCbCp~mlNJWwJx@jBNwWUz@UsppxkCbe}rhh?^]lNIhh~D?lNIhhzx@lNIg{Jx@ZJNn@O^mlNKaO~_lY~qhhvbc}zwaOvbc NI17-0240 ej^\JD@L@bhDKDa`@`fPrRPjJQIGKJZIJJZIIKDqsyFGEZ`jBJfjf@@@HBCJ@@ Pharmaron PH-VIN-0090 Single stereoisomer 0.0085325 1 0.0458 g 99 E06645-116A1 2020-04-23 Highly Unstable in Mouse Plasma 1.69 0.0240.036 N.A. 1.69 =ntztsiw_qAeUo8lXAHcW89MWVh0g7l244Hg2GlF0OoW6960_a4pBN0WV1eFcB1V#4d2Z@820G!W8FF !B_P`B]w]}BHKwPgx@ROwWPp`BB@KwPdc}utLH`d`C@W|H`d`C_`@H`c]|_`AH@wx@]{tH``E?Mwpw?D`CR@MwoPE?R@L NI17-0239 elZRJD@LIGDhDM@f`@aFPrRPjIIKKJZIJJZIIKEPrxGzEZ``biji`@@B@`b`@ Pharmaron PH-VIN-0082 Single stereoisomer 0.07958 1 0.0526 g 99 E06645-119A1 2020-04-23 0.423 NaN =ntztNiwWqAeUo8lXAHcW89MWVh0g7l244Hg2GlF0OoW6960_a4pBN0WV1eFcB1V#4d24@8!G!Y8GF !B[S@RSt}mLAKWwJx@ZNLOwS@RLAKWwFccLAIhxyE?LAIhxzx@LAHW{Jx@ZNNn@D}mLAJQ_q_lE~qhxvccSvvQ_vcc NI17-0238 edRRJD@LFKHhDMOJ`@bFPrRPjIIHiSQIQSQIIXjFG_O@kTDDTuTp@@A@PAP@ Pharmaron PH-VIN-0079 Single stereoisomer 1 0.0852 g 99 E06645-125A1 2020-04-23 4.89 0.419 4.89 ;vzvtzvwiyWqQyUwPtXQHuf89rdWC2gMnr54mg2GlO6OpYDA7X_aMrC@VdcEuFcC1V0XVZt24DB04K04W8F0 !B_X`Bm{]}b@Jw@ox@bGwMIE|EARBw@h`Bb@Ig?ox@bOvH@hc}?g~H@hc}?`BH@k\B?`BH?_x@mwvH@oy?mpJw@hc}bGvw?_y?bGt NI17-0237 efU\JD@LHjhDMLi`@bfPrRPjJQQHjiSQIQSQIIXrNJNVA@xhdkTETEEMUL@@@U@PEP@ Pharmaron PH-VIN-0078 Single stereoisomer 0.034805 1 0.0291 g 98 E06645-107A1 2020-04-16 0.1840.110 NaN =ntztuiw_qAizw8lXQHuWc9MdWh2gMnX54mg2GlO6OpW6A7V_aprC8VdcEuFcC1V0VV4d2ZDB04KF4W8F0 !BW_@b}?]]|BJw?Ez@JDM_APT`UsspHo@bARC~@BaC|BHhPrF?|BHhPuz@|BIWOEz@JDM^`O]]|BHaou\|UsphPraC}utaoraC NI17-0236 ejQ\FD@L@bhDEKDa`@`fPrRPjJJIYUJZIJJZIIKFRpssyFGEZ`jBbfjf@@@J@`r`@ Pharmaron PH-VIN-0077 Single stereoisomer 0.029645 90.95 1 0.0232 g 99 E06645-106A1 2020-04-16 *%Stability at 6 Hr 97.51**%Stability at 6 Hr 85.22 61.67 34.34064356 76.06795571 73.46040224 0.0690.038 0.434726155 14.92877594 59.55 23.28 **95.77 45.85 57.80 57.80 23.98 90.60* 36.66 2.01 15.72 7.82 104.08 88.17 94.21 101.40 91.18 79.35 95.68 73.64 49.165 ;vzvtzvwiyWqQyUwPtXQHuf89rdWC2gMnr54mg2GlG0OpYDA7X_aMrC@VWdCfFcB1V2a0ot24EB04G14W8F0 !B?X`Bm{]}bOrw@ox@bOvo}^]q}YBH@hc|}YC~@Ha}mpJH@ha}?g~H@ha}?`BH@k\B?`BH__x@m?vH@oy?mpJw@ha}bOvw?_y?bOt NI17-0235 efU\JD@LHjhDGLi`@bfPrRPjJQIFEYSQIQSQIIXrVJVF^@xhdkTEPTUMUL@@@U@PEP@ Pharmaron PH-VIN-0075 Single stereoisomer 1 0.0550 g 99 E06645-099A1 2020-04-16 1.5530.531 102.11 13.57 51.00 24.65 27.17 56.24 NaN ;vzntztsiwWqAiUw8lXQHuW89MdWC2gMnX54mg2GlO6OpW6A7V_aKrC8VdcEuFcC1V0VV4d24DB04K!W8F0 !BW_@b}?]]|BJw@ez@JDNw_U\||BKpHox@JDOpHbaCH[?pHbaCWhCpHe\|Wh@hPuz@}uwpHbF?UsqWOBaCJDOwWRF?JDL NI17-0234 elZ\JD@LGDhDI@f`@aFPrRPjIQYEJZIJJZIIKGRrxGzEZ`hHiji`@@B@`b`@ Pharmaron PH-VIN-0076 Single stereoisomer 0.05746 96.84* 1 0.0363 g 99 E06645-090A1 2020-04-09 *%Stability at 6hr = 110.53**%Stability at 6hr = 74.98***%Stability at 6hr = 68.56 17.34 10.01 70.17 65.00 0.15 1.41 14.16 97.04*** 92.58** 17.34 =ntztuiw_qAizw8lXQHuWc9MdWh2gMnX54mg2GlG0OpW6A7V_aprC8VWdCfFcB1V2Z0Jd2ZEB04G14W8F0 !BWW@bCp}]|BJw?Ex@rLM_APT`\BKpH`T`W`CHpynd|BKHprE?|BKHpux@|BKWwEx@rLM^@O]]|BHa_}_\u}sHp|cC}uta_|cC NI17-0233 ejQ\FD@L@bhDCKDa`@`fPrRPjJIKPkJZIJJZIIKFPsQsyFGEZ`hJJfjf@@@J@`r`@ Pharmaron PH-VIN-0074 Single stereoisomer 0.11635 1 0.0448 g 99 E06645-098A1 2020-04-09 1.070.426 NaN ;vzntztsiwWqAiUw8lXQHuW89MdWC2gMnX54mg2GlG0OpW6A7V_aKrC8VWdCfFcB1V2Z0Jd24EB04G14W8F0 !BWW@bCp}]|BJw?Ex@rLNw?W@b|BI^@LcCfzSpHlcCHW?pHlcCW`CpHm_\W`CHpux@}uwpHbE?u}sWwLcCrLOwWRE?rLL NI17-0232 elZ\JD@LGDhDM@f`@aFPrRPjIKSKJZIJJZIIKEPrxGzEZ``biji`@@B@`b`@ Pharmaron PH-VIN-0073 Single stereoisomer 1 0.0392 g 99 E06645-097A1 2020-04-09 1.44 NaN :UvzvtzvRjwWqQvUo8lXAHcf8AMWVC0g7l244mg2GlF0OoY6960_a6pB80WV5eFcB1V0V04d34@8!G!W8F0 !BWW@bCp}]|BJw?Ex@rDNw?W@b|BJw?LcCm?w~@O@bJLLa_?@bJLM^@O@bU}q^@BcCW`CwW_@bHW?WwE_\JLLhp?]]HW|hpp NI17-0231 ebVRBD@LMOLhDHn`@cFPrRPjIIKQESQIQSQIIXjFOP`hkTDDUSUS@@@DA@e@@ Pharmaron PH-VIN-0072 Single stereoisomer 1.0753 1 0.0562 g 99 E06645-085A1 2020-04-01 0.935 NaN ;vzvtzvRjwWrQvUo8lXAHcf8AMWVC0g7l244Hg2GlF0OoY6960_a6pBN0WV1eFcB1V#4d34@8!G!j8MF !BWW@bCp}]|BJw?Ex@rLNw?W@b|BJw?LcCm?w~@O@bJLLa_?@bJLM^@O@bU}q^@BcCW`CwW_@bHW?WwM_\rLOHp?]]HW|hpsSU?H`@?` NI17-0230 enQZFD@LFMOLhDHnbVP@cFPrRPjIIKQESQIQSQIIXcIPqzDEEZ``bjZjX@@@f@`R`@ Pharmaron PH-VIN-0070 Single stereoisomer 1 0.0373 g 99 E06645-088A1 2020-04-01 1.594 NaN =ntztsiw_qAeUo8lXAHcW89MWVh0g7l244Hg2GlF0OoW6960_a4pBN0WV1eFcB1V#4d2Z@8!G!W8FF !BwW@bCp}]|BJw?Ex@rLNw?W@b|BJw?LcCm?wpHlcCHW?pHlcCW`CpHm_\W`CHpux@}uwpHbE?u}sWwLcCrLOwWRE?rLL NI17-0229 elZRJD@LFGDhDM@f`@aFPrRPjIIKKJZIJJZIIKEPrxGzEZ``biji`@@B@`b`@ Pharmaron PH-VIN-0069 Single stereoisomer 0.0677 1 0.0476 g 98 E06645-087A1 2020-04-01 0.342 NaN =ntztsiw_qAeUo8lXAHcW89MWVh0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d2Z@8!G!W8F0 !BWW@bCp}]|BJw?Ex@rLNw?W@b|BJw?LcCm?wpHlcCHW?pHlcCW`CpHm_\W`CHpux@}uwpHbE?u}sWwLcCrLOwWRE?rLL NI17-0228 elZ\JD@LGDhDM@f`@aFPrRPjIIKKJZIJJZIIKEPrxGzEZ``biji`@@B@`b`@ Pharmaron PH-VIN-0071 Single stereoisomer 0.020925 1 0.0515 g 99 E06645-084A1 2020-03-26 1.35 0.074 1.35 =v:xzyzpqfuUrglYAHclc9U_cSVgEl2J5Hg2llF0OoW6968ba4pBNFWV1eFcB1V4014d24@@!G!W8FF !BW_@b}?]]|BJw@ez@JDNw__x@|BKpHk\BmpHhP?x@|BHhPrF?|BHhPuz@|BIWOEz@JDM^`O]]|BHaou\|UsphPraC}utaoraC NI17-0227 ejQRJD@LF@bhDODa`@`fPrRPjJIIK[JZIJJZIIKGQrssyFGEZ`hJJfjf@@@H``r`@ Pharmaron PH-VIN-0068 Single stereoisomer 0.043 1 0.0601 g 98 E06645-089A1 2020-03-26 1.54 0.049 0.794 1.54 =ntztuiw_qAizo8lXAHeWc9MWVh0g7l244mg0GlF0OoW6960_aZpB80WV5f0c41V!84d2Z@8!J!W8F0 !B?X`BM{]}b@Jw?H`C_hA_APT`B@HA_p`BARBH@wx@ROvH@`F?bOw~_t`BbGw~`Oy?b@Jw_Xa}?`BH?X`B?g~H@h`BbGvH_Xa}?g~H_P NI17-0226 en]\JD@LHfhDKBe`@afPrRPjJJIZHpzZIJJZIIKFRpspIJDgFeZ`hB@bZjX@@@h@`j`@ Pharmaron PH-VIN-0058 Single stereoisomer 0.1047 1 0.0653 g 99 E06645-082A1 2020-03-26 14.45 0.181 14.45 =v;vy:yAijpRtufqjrfdr_Vo5jEl2Bqmg8FnkVSoWLC61l_ipB84WV5fcVJ9VF08Bd2Z@8!g!W0F0 !B_X`Bm{]}b@Jw@hc}?`A_APT`b@K~_x`BARBH__x@bGvH@oy?bGw~_x`BbGw~@Oy?b@Jw_Xa}?`BH_X`B?g~H?H`BbGvH?Xc}?g| NI17-0225 efU\JH@LHfhDKBe`@cIIBhhhehcCihdhihddmIXYxDeBScRmPTA@QMULEAQPEAU@@ Pharmaron PH-VIN-0055 Single stereoisomer 0.51555 1 0.0432 g 98 E06645-081A1 2020-03-26 0.76 10.934195 75.58645989 74.95261864 0.7230.5770.583 1.196248408 13.08001336 >10 0.76 :Uvzv;S:vyfzExTsuvyzrEdzhYJ5jU_qCrmhsNntVxMYTEKWl_@hgBaWWMvc0oCdq2Pwl34A81JiG4W0F0 !B_X`Bmza\mwupGVD@mpJhWAy?jErw__x@mpIpGVD@\AvhWAy?bGw~_x`BbGw~@Oy?b@Jw_Xa}?`BH?Xc|?g~H@hc|bOvH?Xa}?g| NI17-0224 efYRBH@LBHfhDBe`@cIICDheHhgCihdhihddlixDeBScRmUAUDQMULEAQPTET@@ Pharmaron PH-VIN-0060 Single stereoisomer 1.4 1 0.0518 g 99 E06645-047A1 2020-03-19 1.658 NaN :UvzntztNjwWqAjUo8lXAHeW89MWVC0g7l244mg0GlF0OoW69L0_a4pB80WV5f0d41V!84d24@8!J!W8F0 !B?X`BM{]}b@K~o{_|b@M~`@`B@W|H@h`C_`AH?X`B@[~H?_y?R@JH__z@?g~H@k]}bGw~@Hc}b@K~_x`Bb@JH_Xa}bGw~_xa} NI17-0223 ejQ\BD@LOBhDDa`@`fPrRPqPqJKPzZIJJZIIKGRqpKyFGEZh@@Hfjf@@@H@`r`@ Pharmaron PH-VIN-0057 Single stereoisomer 1 0.04 g 99 E06645-070A1 2020-03-19 >10 NaN :Uvzv;O:vyAjEpRtufqjMAdr_VJ5jEl2Bqmg8FnkVSoWLBJ1l_DpB84WV5fcWJ9VF08Bd24@8!g!W0F0 !B_X`Bm{]}b@Jw@oy?bOw~@H`B?g~H@ha}?`BH_X`B?g~H__y?b@JH__x@?g~H@k]}bGw~@Ha}bOs~_x`Bb@JH?Xa}bGw~_p NI17-0222 eb^\BH@LOBhDDa`@cIICECDhmCihdhihddmiXxE|cCbmT@@DSUSAPTPEAe@@ Pharmaron PH-VIN-0054 Single stereoisomer 1 0.0624 g 99 E06645-069A1 2020-03-19 >10 NaN :Uvzv;O:vyfjExRsuvyzrEdzhYJ5jU_XCrmh8NntVxMWLEKWl_@_g8ZWWMvc0oCdq0@RW34A81JiG4W0F0 !B_X`Bmza\mwupGVD@mpJhWAy?jErw_W@]XPApGZa\Gg~H__y?b@JH__x@?g~H@k]}bGw~@Hc}b@K~_x`Bb@JH?Xc}bOw~_p NI17-0221 eb^RBH@LBOBhDDa`@cIICDhdhcCihdhihddliXxE|cCbmUAQDSUSAPTTEAe@@ Pharmaron PH-VIN-0059 Single stereoisomer Did not calculate, about 2? 1 0.0349 g 99 E06645-046A1 2020-03-12 >10 NaN :UvzntztNiwWqAiUo8lXAHeW89MWVC0g7l244mg0GlF0OoW6960_a4pB80WV5f0c41V!84d24@8!J!W8F0 !B?X`Bm{_}^KQ??aAUjTA}mwbtec}xmAAUjT@PUWbtec?hDuE?^KPPUZe@ec}xm@^KDEViPAAU^KRVOwbt^KPPUQAUDEVVOqAU NI17-0220 ejQ\BD@LOBhDDa`@`fPrRPjIQZKPzZIJJZIIKGRqpKyFGEZ``@Hfjf@@@H@`r`@ Pharmaron PH-VIN-0056 Single stereoisomer 0.007396 1 0.0571 g 99 E06645-076A1 2020-03-12 0.48 0.172 0.48 :Uvzv;OyzvyAiEpRtufqjMAdr_VJ5jEl2Bqmg8FnkVSoWLB41l_DpB84WV5fcVJ9VF08Bd24@8!g!W0F0 !BfzS|myn[jIq_^g@]XPB[fzb\Gg~hgG@]XPApGZb\Gg|DJyg_jIqpGVD@Gg~hgI^c\Aua@G@]jIp^_zb\jIqpGW@]\At^_p NI17-0219 eb^\BH@LOBhDDa`@cIIBheEhmCihdhihddmiXxE|cCbmPP@DSUSAPTPEAe@@ Pharmaron PH-VIN-0053 Single stereoisomer 0.022585 1 0.0913 g 99 E06645-075A1 2020-03-12 0.441 NaN :UvzntztNiwWqAeUo8l2AHcW89MWVC0g7l244mg2GlF0OoW6160_a4pBN0WV5eFcB1V0V04d!@8!G!W8FF !B_X`Bm{]}b@Jw@h`CohA_APT`B@HH@`T`ohBH@hc}?g}H@ha}?hC~_x`BmwvH_Xc}?`BH@oy?b@JH@ha}bGw~@Oy?bGt NI17-0218 elVRBD@LGDahD@f`@aFPrRPjJIKEJZIJJZIIKFPsRrxGzEZ`hHiji`@@B`HHh@@ Pharmaron PH-VIN-0064 Single stereoisomer 0.018765 1 0.0193 g 99 E06645-053A1 2020-03-05 7.22 0.324 7.22 :UvzvtzvRiyWqQuUoPt2AHcf89rWVC0g7lM44mg2GlF0OoYD162_a6pBP0WV5eFcB1V0X0Zt!@8!G!W8FF !B_T`BMs]}r@Hw@hc}_l@_^Wf`A}YH@d`B~ZA~pD`BRGw~o|bBRGw~pOz?b@Jw_\b}R@M~PDaB@W}H`dbBRGuH_Wz@@[}H_P NI17-0217 ebQRBD@LOLihDHn`@cFPrRPjJQIDiSQIQSQIIXrVJVFNOP`hkTEPQSUS@@@EPDBT@@ Pharmaron PH-VIN-0063 Single stereoisomer 0.105055 1 0.0243 g 99 E06645-054A1 2020-03-05 41.20 3.32 71.19 73.57 0.456 3.87 12.86 196.58 7.05 252.26 79.82 5.49 17.36 41.2 =ntztuiw_qAezo8l2AHcWc9MWVh0g7l244mg2GlF0OoW6160_aZpBN0WV5eFcB1V0V04d0V@8!G!W8FF !B_X`Bm{]}b@Jw@h`CohA_APT`B@HH@`T`ohBH@hc}g}H@ha}hC~_x`BmwvH_Xc}`BH@oyb@JH@ha}bGw~@OybGt NI17-0216 elVRJD@LGDahDC@f`@aFPrRPjJIKEJZIJJZIIKFPsRrxGzEZ`hHiji`@@B`HHh@@ Pharmaron PH-VIN-0062 Single stereoisomer 0.08484 1 0.0244 g 99 E06645-056A1 2020-02-27 0.976 NaN :UvzntztNiwWqAeUo8l2AHcW89MWVC0g7l244mg2GlF0OoW6160_a4pBN0WV5eFcB1V0V04d!@8!G!W8FF !B_X`Bm{]}b@Jw@h`CohBw_P`BB@J~`H`BbOw~_t`BbGw~`Oyb@Jw_Xa}bOw~@H`Bg~H@h`BbGvH__x@g~H_P NI17-0215 eh\RBD@LC@fhDGB`@`FPrRPjIKYJZIJJZIIKESSYz{yZ``JZjX@@@`HOH@@ Pharmaron PH-VIN-0061 Single stereoisomer 0.058145 1 0.0358 g 99 E06645-055A1 2020-02-27 3.53 0.604 3.53 =ntztuiw_qAezo8lXAHcWc9MWVh0g7l244Hg2GlF0OoW6960_aZpBN0WV1eFcB1V#4d2Z@820G!W8FF !BU[PjbxmUmBibc{Dc@t[z^edmBjtJnedc@vtJhpMp]ntJhpMwlRtJkMrwlRLCS{DbuVtJdG[lwJs\hpMc@vKUTG[c@t NI17-0214 elVRJD@LEGDhDC@f`@aFPrRPjJIKEJZIJJZIIKFPsRrxGzEZ`hHiji`@@B`HHh@@ Pharmaron PH-VIN-0050 Single stereoisomer 0.059 89.18 1 0.0471 g 99 E06645-009A1 2020-02-20 *Unstable in Mouse Plasma**2% BSA Added 17.22 6.89 81.66 75.07 0.223 **1.66 11.42 141.536393267406 9.79 *84.42 102.70 73.64 13.50 18.82 17.22 :UvzvtzvRiyWqQuUoPtXAHcf89rWVC0g7lM44Hg2GlF0OoYD962_a6pBP0WV1eFcB1V020Zt24@820G!W8FF !BYVpZDqMe[IhOZcztgMTi}NLUxvilffrZ_rV\uVrZgMUAbvrZgMT~mFrZh|h~mIsUOkPSiVrZPXncrjOJgMV\uQNePXn\uP NI17-0213 ebQRBD@LMOLhDHn`@cFPrRPjJQIDiSQIQSQIIXrVJVFNOP`hkTEPQSUS@@@EPDBT@@ Pharmaron PH-VIN-0049 Single stereoisomer 0.056 97.92 1 0.0466 g 99 E06645-008A1 2020-02-20 *Compoudn is highly unstable in mouse plasma**2% BSA Added 0.36 0.98 68.58 72.15 0.236 **6.27 6.14 120.74 11.48 N.A.* 4.68 7.03 8.69 1.24 81.08 98.11 97.51 99.68 NA 2.52 =ntztuiw_qAezo8lXAHcWc9MWVh0g7l244Hg2GlF0OoW6960_aZpBN0WV1eFcB1V#4d2Z@8!G!W8FF !BU[PjbxmUmBibc{Dc@t[z^edmBjtJnedc@vtJhpMp]ntJhpMwlRtJkMrwlRLCS{DbuVtJdG[lwJs\hpMc@vKUTG[c@t NI17-0212 elVRJD@LFGDhDC@f`@aFPrRPjJIKEJZIJJZIIKFPsRrxGzEZ`hHiji`@@B`HHh@@ Pharmaron PH-VIN-0047 Single stereoisomer 0.069 86.73 1 0.0451 g 99 E06645-034A1 2020-02-20 *Unstable in Mouse Plasma**2% BSA Added 11.91 13.43 91.26 87.90 0.159 **0.69 9.26 217.31 6.38 *93.71 11.91 :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244Hg2GlF0OoW6960_a4pBN0WV1eFcB1V#4d24@820G!W8FF NI17-0211 eh\RBD@LIC@hDGB`@`FPrRPjIKYJZIJJZIIKESSYz{yZ``JZjX@@@`HOH@@ Pharmaron PH-VIN-0048 Single stereoisomer 0.042 93.77 1 0.0479 g 99 E06645-010A1 20200213 *Unstable in Mouse Plasma**2% BSA Added 2.03 1.78 71.16 71.42 0.335 **5.54 9.85 92.11 15.05 *78.03 2.03 :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244Hg2GlF0OoW6960_a4pBN0WV1eFcB1V#4d24@8!G!W8FF NI17-0210 eh\RBD@LFC@hDGB`@`FPrRPjIKYJZIJJZIIKESSYz{yZ``JZjX@@@`HOH@@ Pharmaron PH-VIN-0045 Single stereoisomer 0.055 92.26 1 0.0621 g 99 E06645-033A1 20200213 *Unstable in Mouse Plasma**2% BSA Added 1.32 6.48 87.58 78.83 0.180 **2.77 17.95 124.84 11.10 *90.58 1.32 :UvzvtzvRiyWqQuUoPtXAHcf89rWVC0g7lM44Hg2GlF0OoYD962_a6pBP0WV1eFcB1V020Zt24@8!G!W8FF !BYVpZDqMe[IhOZcztgMTi}NLUxvilffpZ_rV\uVrZgMUAbvrZgMT~mFrZh|h~mIsUOkPSiVrZPXncrjOJgMV\uQNePXn\uP NI17-0209 ebQRBD@LFOLhDHn`@cFPrRPjJQIDiSQIQSQIIXrVJVFNOP`hkTEPQSUS@@@EPDBT@@ Pharmaron PH-VIN-0046 Single stereoisomer 0.040 95.23 1 0.0422 g 99 E06645-037A1 2020-02-20 *Unstable in Mouse Plasma**2% BSA Added 1.79 3.66 74.58 76.52 0.073 **2.60 9.52 314.47 4.41 *83.58 207.42 60.04 6.68 23.09 0.398 17.93 3.36 10.58 3.14 84.57 91.54 95.77 105.57 97.47 79.98 82.47 4.37 9.86 :UvzntztNiyWqAiUwPlXAHcl89rdYC0g7lM4Bmg2GlF0OoWD962_a4pg80WV5eFcR1V0Y0Zt24A8!l08WNF0 NI17-0208 el^\BD@LKHhDON`@aFPrRPjJIGISRIIQKQIHxRSPrijyxFEZ`hBfjjX@@B`@@@ Pharmaron PH-VIN-0038 No stereochemistry 1 0.029 g 98 E06645-025A1 20200119 >10 NaN :UvzvtzvRiyWqQyUwPtXAHcv89rdYC0g7lM4Bmg2GlF0OoYD962_a6pg@0WV5eFcR1V0Y0Zt24A8!l08W8F0 NI17-0207 ejU\BD@LOLhDHi`@`fPrRPjJQIDiSRIIQKQIHzRqRpqsh[xEGEZ`jBJZji`@@J`@@@ Pharmaron PH-VIN-0037 No stereochemistry 0.940 1 0.0188 g 99 E06645-026A1 20200119 >10 NaN =ntztuiy_qAizwPlXAHclc9rdYh0g7lM4Bmg2GlF0OoWD962_aZpg80WV5eFcR1V0Y0Zt2ZA8!l08W8F0 NI17-0206 ebQ\JD@LGDhDC@a`@cFPrRPjJIKEJZQIJIZIIGRFZVM]O_PhkTEAEMUTp@@E@@@@ Pharmaron PH-VIN-0036 No stereochemistry >10 1 0.031 g 99 E06645-023A1 20200119 >10 NaN :Uvzvt:RjyWqQvUoQt2APcj89rWkC9g7pM64miHIlF8OwYD1L2_i6xBP0WV5eHdB1k0XFZt10P8!G!W8FF NI17-0205 ejYRBD@LOLghDHa`@`fPrRPjJQIDiSQQJZZIIKFRqRpqsyFGEZ`jBJZjf@@@J`HDh@@ Pharmaron PH-VIN-0044 Single stereoisomer 5.817 1 0.0575 g 98 E06645-039A1 20200116 5.244 NaN :UvzvtzxRjwWqAvUoQl2APcb89MWkC9g7pL64miHIlF8OwYD1L0_i4xBN0WV5eHdB1k0XFZt10P8!G!W8FF NI17-0204 ebVRBD@LGDkhD@n`@cFPrRPjJQJyJZJISSQIIXfVOP`hkTEPEMUS@@@DAAE@@ Pharmaron PH-VIN-0043 Single stereoisomer 0.832 87.58 1 0.0235 g 99 E06645-036A1 20200116 *%Stability at 6 Hr 57.41 0.570 82.89* NaN :UvzntztNiyWqAiUwPlXAHcl89rdYC0g7lM4Bmg2GlF0OoWD962_a4pg80WV5eFcR1V0Y0Zt24A8!l08W8F0 NI17-0203 edZ\BD@LC@hDGF`@bFPrRPjIKYJZQIJIZIIGJZEUGW_@kTDASUUL@@A@@@@ Pharmaron PH-VIN-0035 No stereochemistry 4.434 1 0.0429 g 99 E06645-022A1 20200116 >10 NaN :UvzvtzvRiyWqQuUoPtXAHcf89rWVC0g7lM44mg2GlF0OoYD962_a6pB@0WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0202 ebQ\BD@LOLhDHn`@cFPrRPjJQIDiSQIQSQIIXrVJVFNOP`hkTEPQSUS@@@EPDBR@@ Pharmaron PH-VIN-0052 Single stereoisomer >10 1 0.0333 g 99 E06645-015A1 20200108 >10 NaN :UvzvtzxRjwWqAvUo9l2APcb89MWkC9g7p264miHIlF8OwY61L0_i4xBN0WV5eHdB1k0VF4d10P8!G!W8FF NI17-0201 edRRBD@LC@mhDGJ`@bFPrRPjIKYJZJISSQIIXjZG_O@kTDASUTp@@A@P^P@ Pharmaron PH-VIN-0041 Single stereoisomer >10 1 0.0268 g 99 E06478-089A1 20200108 2.890 NaN :UvzvtzvRiyWqQyUwPtXQHuf89rdYB0g7nr54mg3GlN2OpYD96X_a6pCPVWVEeFVB1V0X0at24D8!K04W8FF NI17-0200 ejYRBD@L@bchDDa`@`fPrRPjJQQHuJZIJJZIIKFQqQrssyFGEZ`jHbfjf@@@J`HLh@@ Pharmaron PH-VIN-0031 Single stereoisomer 0.103 1 0.1004 g 99 E06478-093A1 20200102 0.236 NaN :UvzvtzvRiyWqQyUwPtXQHuf89rdYB0g7nr54mg3GlF0OpYD96X_a6pCPVWWCfFVB1V2a0at24E8!G14W8FF NI17-0199 ejYRBD@L@bchDDa`@`fPrRPjJQIFGJZIJJZIIKFRqRpqsyFGEZ`jBJfjf@@@J`HLh@@ Pharmaron PH-VIN-0030 Single stereoisomer 0.394 1 0.0188 g 99 E06478-080A1 20200102 0.979 NaN :UvzntztNiwWqAiUwPlXQHuW89MdYC0g7nq54mg3GlN2OpWD96V_a4pC8VWVEeFcB1V0X0at24D8!K04W8F0 NI17-0198 ebV\BD@LOLhDHn`@cFPrRPjJQQTiSQIQSQIIXvNOP`hkTEQASUS@@@DA@e@@ Pharmaron PH-VIN-0029 Single stereoisomer 0.077 1 0.0594 g 99 E06478-087A1 20200102 *2% BSA Added 2.15 1.05 57.58 69.46 0.018 *4.76 5.02 2.15 :UvzvtzvRiyWqQuUoPtXAHuf89rWVB0g7lM44mg3GlF0OpYD962_a6pB@0WV5eFcB1V2a0Zt24@8!G!W8F0 NI17-0197 ebQ\BD@LOLhDHn`@aFPrRPjJQIDiSQIQSQIIZRVJVFNOP`xkTEPQSUS@@@QPDBT@@ Pharmaron PH-VIN-0034 Single stereoisomer 0.104 1 0.1074 g 99 E06478-067A1 20191230 0.346 NaN =ntztuiw_qAezo8lXAHuWc9MWVg0g7l244mg3GlF0OpW6960_aZpB80WV5eFcB1V2Z04d2Z@8!G!W8F0 NI17-0196 elV\JD@LGDhDC@f`@bFPrRPjJIKEJZIJJZIIKRPsRrxGyEZ`hHiji`@@H`HHh@@ Pharmaron PH-VIN-0033 Single stereoisomer 0.141 1 0.0497 g 99 E06478-066A1 20191230 0.165 NaN :UvzntztNiwWqAiUwPlXQHuW89MdYC0g7nq54mg3GlF0OpWD96V_a4pC8VWWCfFcB1V2a0at24E8!G14W8F0 NI17-0195 ebV\BD@LOLhDHn`@cFPrRPjJQJsYSQIQSQIIXfVOP`hkTEPESUS@@@DA@e@@ Pharmaron PH-VIN-0028 Single stereoisomer 0.107 98.07 1 0.0542 g 97 E06478-076A1 20191230 *2% BSA Added**%Stability at 6 hr 54.52 0.58 1.13 62.73 74.72 0.034 *6.67 7.53 96.34** 0.58 :UvzntztNiwWqAeUo8lXAHcW89MWVB0g7l244mg2GlF0OoW6960_a4pBN0WV5eFVB1V0V04d24@8!G!W0FF NI17-0194 edZRBH@LGDghD@f`@cIIBhhdlTihdhihddmHYiY\C}BmPTDTuTp@@A@PQP@ Pharmaron PH-VIN-0026 Single stereoisomer 0.236 1 0.0511 g 99 E06478-041A1 20191219 0.659 NaN :Uvzn:tNizlqAeUp8tXAHcl89M_VB0g7l244mg2GlF0OoW6964_a4pBN0WV5eFVB1V0V04d24@8!G!W0FF NI17-0193 elVRBH@LOLohDHn`@cIIBhhddjeMDeEMDdemGCKGhPTUjB`hiji`@@@``R`@ Pharmaron PH-VIN-0025 Single stereoisomer 0.070 1 0.0357 g 99 E06478-040A1 20191219 *2% BSA Added 10.60 9.87 82.47 79.75 0.235 *1.34 13.25 1.259 10.6 =vtzxyjw_qAvzo9l2APcbc9MWkh9g7p264miHIlF8OwY61L0_iZxBN0WV5eHdB1k0VF4d1VP8!G!W8FF NI17-0192 eb^RJD@LGDkhDC@n`@cFPrRPjJIKEJZJISSQIIXrFZVOP`hkTEAEMUS@@@E@PQP@ Pharmaron PH-VIN-0013 Single stereoisomer 2.831 1 0.0885 g 99 E06478-061A1 20191219 >10 NaN :UvzvtzvRiyWqQuUoPtXAHcf89rWVB0g7lM44mg2GlF0OoYD962_a6pBP0WV5eFVB1V0X0Zt24@8!G!W0FF NI17-0191 el^RBH@LOLohDHn`@cIIBhiDdReMDeEMDdeiKEKCGGhPTUjBhHiji`@@B`HDh@@ Pharmaron PH-VIN-0024 Single stereoisomer 0.651 1 0.0432 g 99 E06478-039A1 20191212 1.162 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVB0g7l244mg2GlF0OoW6960_a4pBN0WV5eFVB1V0V04d24@8!G!W0FF NI17-0190 edZRBH@LGDehD@f`@cIIBhhdlTihdhihddmHYiY\C}BmPTDTuTp@@A@PQP@ Pharmaron PH-VIN-0022 Single stereoisomer 0.230 1 0.0288 g 98 E06478-049A1 20191212 1.114 NaN :Uvzn:tNizlqAeUp8tXAHcl89M_VB0g7l244mg2GlF0OoW6964_a4pBN0WV5eFVB1V0V04d24@8!G!W0FF NI17-0189 elVRBH@LOLmhDHn`@cIIBhhddjeMDeEMDdemGCKGhPTUjB`hiji`@@@``R`@ Pharmaron PH-VIN-0021 Single stereoisomer 0.231 1 0.0485 g 97 E06478-048A1 20191212 0.220 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVB0g7l244mg2GlF0OoW6960_a4pBN0WV5eFVB1V0V04d24@8!G!W8FF NI17-0188 elVRBD@LGDehD@f`@aFPrRPjJIKEJZIJJZIIKFPsRrxGzEZ`hHiji`@@B`HHh@@ Pharmaron PH-VIN-0018 Single stereoisomer 0.209 1 0.044 g 99 E06478-047A1 20191212 *2% BSA Added 2.61 1.03 54.18 68.61 0.114 *5.24 5.40 0.251 2.61 :Uvzn:tNizlqAeUp8tXAHcl89M_VB0g7l244mg2GlF0OoW6964_a4pBN0WV5eFVB1V0V04d24@8!G!W8FF NI17-0187 eb^RBD@LOLmhDHn`@cFPrRPjJIIJiSQIQSQIIXzNFVOP`hkTEAQSUS@@@DPPIP@ Pharmaron PH-VIN-0017 Single stereoisomer 0.185 1 0.0501 g 99 E06478-046A1 20191212 2.73 0.067 2.73 :UvzntztNiwWqAeUoPlXAHuW89MWVB0g7lL44mg3GlF0OpWD960_a4pB80WV5eFcB1V2a0Zt24@8!G!W8F0 NI17-0186 elZ\BD@LGDhD@f`@bFPrRPjJQJyJZIJJZIIKPrrxGyEZ`j@iji`@@H@`b`@ Pharmaron PH-VIN-0032 Single stereoisomerIn Mitobridge Patent 0.0426 1 0.0631 g 99 E06478-050D1 20191205 0.061 NaN :UvzvtzvRiyWqQuUoPtXAHcf89rWVB0g7lM44mg2GlF0OoYD962_a6pBP0WV5eFVB1V0X0Zt24@8!G!W0FF NI17-0185 el^RBH@LOLmhDHn`@cIIBhiDdReMDeEMDdeiKEKCGGhPTUjBhHiji`@@B`HDh@@ Pharmaron PH-VIN-0020 Single stereoisomer 0.218 1 0.033 g 98 E06478-042A1 20191205 1.642 NaN :UvzvtzvRiyWqQuUoPtXAHcf89rWVB0g7lM44mg2GlF0OoYD962_a6pBP0WV5eFVB1V0X0Zt24@8!G!W8FF NI17-0184 ebQRBD@LOLmhDHn`@cFPrRPjJQIDiSQIQSQIIXrVJVFNOP`hkTEPQSUS@@@EPDBT@@ Pharmaron PH-VIN-0016 Single stereoisomer 0.0418 1 0.0376 g 98 E06478-045A1 20191205 *2% BSA Added 7.41 0.71 46.07 67.21 0.180 *4.27 3.04 7.41 :UvzntztNiwWqAeUoPlXAHcW89MWVB0g7lL44mg2GlF0OoWD960_a4pBN0WV5eFVB1V0X0Zt24@8!G!W0FF NI17-0183 edRRBH@LGDghD@f`@cIIBhiDkdihdhihddlYY\C}BmPU@TuTp@@@AAE@@ Pharmaron PH-VIN-0023 Single stereoisomerIn Mitobridge Patent 0.249 1 0.0617 g 95 E06478-035A1 20191128 0.119 84 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVB0g7lL44mg2GlF0OoWD960_a4pBN0WV5eFVB1V0X0Zt24@8!G!W0FF NI17-0182 edRRBH@LGDehD@f`@cIIBhiDkdihdhihddlYY\C}BmPU@TuTp@@@AAE@@ Pharmaron PH-VIN-0019 Single stereoisomerIn Mitobridge Patent 0.150 1 0.0613 g 99 E06478-030A1 20191128 *2% BSA Added 15.73 0.69 60.47 79.09 0.124 82 *6.64 4.60 15.73 :UvzntztNiwWqAeUoPlXAHcW89MWVB0g7lL44mg2GlF0OoWD960_a4pBN0WV5eFVB1V0X0Zt24@8!G!W8FF NI17-0181 elZRBD@LGDehD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ Pharmaron PH-VIN-0015 Single stereoisomerIn Mitobridge Patent 0.137 98.23 1 0.0515 g 98 E06478-036A1 20191128 *%Stability at 6hr 17.48 0.032 88 95.30* NaN :Uvzvt:RjyWqQvUoQtXAPcj89rWkC9g7pM64miHIlF8OwYD9L2_i6xB@0WV5eHdB1k0XFZt34P8!G!W8F0 NI17-0180 ejY\BD@LOLhDHa`@`fPrRPjJQIDiSQQJZZIIKFRqRpqsyFGEZ`jBJZjf@@@J`HDh@@ Pharmaron PH-VIN-0014 Single stereoisomer 1.14 1 0.0563 g 97 E06478-033A1 20191121 7.572 100 NaN :Uvzv;S:tyvvUrCnbfucz8AU_kSOgEp265miHIlF8OwY69L8biBxBDFWX5eHdB1k4VG4d34P8!GV0W8F0 NI17-0179 enURBD@LO@jhDLe`@afPrRPjJIIKYKSQQJZZIIKGQrsrDgFeZ`hJJijjX@@@bB@j@@ Pharmaron PH-VIN-0012 Single stereoisomer 1 0.0253 g 98 E06478-032A2 20191121 >10 1 NaN =vtzxyjw_qAvzo9lXAPcbc9MWkh9g7p264miHIlF8OwY69L0_iZxB80WV5eHdB1k0VF4d3ZP8!G!W8F0 NI17-0178 eb^\JD@LGDhDC@n`@cFPrRPjJIKEJZJISSQIIXrFZVOP`hkTEAEMUS@@@E@PQP@ Pharmaron PH-VIN-0011 Single stereoisomer 1.84 1 0.0463 g 99 E06478-028A1 20191121 6.102 100 NaN =v;vyxzyAezpTlufmh7fdr_VR5j7lLBbmg@GnFVtoWTBZ1pbDpB80WV5esVR1VFX4Zt24@@09t!W0F0 NI17-0177 e`T\JH@LGDhD@fg`@cIIBhiDkdihdhihdlYYl}]|mPU@TuTpTDDPQP@ Pharmaron PH-VIN-0006 Single stereoisomerIn Mitobridge Patent 1 0.0454 g 99 E06478-020A1 20191121 >10 6 NaN :Uvzv;OyzvyAeUpTtufqhMAdr_VR5j7lLBamg@GnkVSoWTB45pbDpB84WV5esVR9VFX0gt24@8!t!W0F0 NI17-0176 eh\\BH@LGDhD@f`@cIIBhiDkdihdhihddcKK`WoejBhBfjfB`hB`b`@ Pharmaron PH-VIN-0005 Single stereoisomerIn Mitobridge Patent 0.0417 95.78 1 0.1136 g 99 E06478-019A1 20191121 *2% BSA Added**Highly unstable in rat plasma, Bound percent reported as N.A. 0.23 1.26 74.32 80.33 0.070 100 *6.16 7.78 N.A.** 0.23 :Uvzv;OyxfyAeUpTlufmh7Adr_VR5j7lLBamg@GnFVOoWDB41pbDpB84WV5esVR1VFX0Zt24@8!t!WFF0 NI17-0175 eoh\BH@LGDhD@f`@cIIBhiDkdihdhihdSKEmkgejBhBfjfB`BHHh@@ Pharmaron PH-VIN-0007 Single stereoisomerIn Mitobridge Patent 105 1 0.0836 g 99 E06478-021A1 20191114 >1.0 -5 NaN :Uvzv;S:vyAvUrTlvfuhMAfr_VRCjjpLDamg@GnkVOoWTB41pbDpBDJWX5euVR1VFX0Zt3J@8!tV0W0F0 NI17-0174 elZRBH@LGDhXD@f`@cIIBhiDkdihdhihddlSKK`_hUjBhBfjfB`hhJBJ@@ Pharmaron PH-VIN-0004 Single stereoisomer 117 1 0.1025 g 99 E06478-018A1 20191114 >1.0 -17 NaN :Uvzv:xNixYqAeUpTlXAHh789M_VR1h7lL47mg2GnkVOoWD840_a4xB80WV5ekVB1VJX0Zt24@8!G!W0F0 NI17-0173 elZ\BH@LGDhD@f`@cIIBhiDkdihdhideEecKCohTUjBhBfjfB@@@BBJ@@ Pharmaron PH-VIN-0003 Single stereoisomerIn Mitobridge Patent 96 1 0.1185 g 99 E06478-016A1 20191114 >1.0 4 NaN :UvztUUxJhxYLAQUMPG39Pda!25VC9c2tL60XhHIVXVOXXB1F0Za4w880YV5VHd83V0XFZt102#G!W8F0 NI17-0172 eo`\BD@LGDhD@j`@azPrRPjJQJyJYQQZIKXrpzyZ`j@ijf``H@@@ Pharmaron PH-VIN-0010 No stereochemistry 88 1 0.0275 g 99 E06478-012A1 20191111 >1.0 12 NaN :UvztUUxJhxYLAQUMPlY9Pda!25VC9g6xL61XhHIlXVOXXB1J0Za4w880YV5VHd83V4XFZt142#G!W8F0 NI17-0171 ebV\BD@LGDhD@j`@aFPrRPjJQJyJYQQZIIQYIFVG_PxkTEPEMTtD@@P@@@@ Pharmaron PH-VIN-0009 No stereochemistry 96 1 0.0497 g 98 E06478-015A1 20191111 >1.0 4 NaN :UvztOUxJCwWHAQUJPG39Pca!21VC9V2tL60XgHIVX0OVXB1F0_a4R880WV5VHd83V0XFZt102#G!W8F0 NI17-0170 elZ\BD@LGDhD@j`@aFPrRPjJQJyJYQQZJIIKXrrxGzEZ`j@ijf`@@B@@@@ Pharmaron PH-VIN-0008 No stereochemistry 84 1 0.0513 g 99 E06478-010A1 20191111 >1.0 16 NaN 2FPF!81&2!8#N0F,V1!82)20V!101F#8*4%2#10VVF NI17-0169 dg^`PL[ml@aPaJVy]\Yk@`jp@@ Sigma SML0430 PR-619 0.072 NaN :UvMlOM1F4RVH3@TNH12OHc!F091B0V2lo58Xc2GV869VVBV!h64J8FV1W5VFV91X0X0Zs!3F!G!W0Fk NI17-0159 fegIb@LNRNB@`BLddJbdRnRfbRRQkEjNZuATASSP@@@@ ChemPartner N/A 1 0.070 g 2 NaN :UvMlOM1F4RVH3@TNH12OHc!F091B0V2lo58Xc2GV869VVBV!h64J8FV1W5VFV91X0X0Zs!3F!G!W0Fk NI17-0158 fegIb@LNSNB@`BLddJbdRnRfbRRQkEjNZuATASSP@@@@ ChemPartner N/A 1 0.019 g 4 NaN :UvztOUxJ5wWHAUURPG2OPcaCF09YC9V2tqE8XgHQZ86OVXBWF0ha4R88VWW5WHd91fVXk_t103F1FG10W8FV NI17-0154 elV\BD@LGDhD@a`@aFPrRPjJQJyJZJIJIZKKXrpikYxFEZ`j@iijF@@B@@@@ Completed - to ship 11/1 ChemPartner 95% purity; 5% impurity is des-4-fluorobenzacyl 1 14 NaN :Uvzv:xRjxYqAzUzUlYAPhb89MhnR9hMxL6CmjHIlviOyYD9L0_i4xg80fV7uHdB3kJXkZt34P8!GFBW0F0 !BPOX|_E@}k|o\b\sT@wqPL\sKwKvoZT@wvow_]UssA_z|uEMnG}BdpD[VPF|u[sT|rLKwJS~G}@CA@LEoMV|upo^G}@ NI17-0148 eb^\BH@LGDhD@n`@cIIBhiDkdihheDiiddlYYL]|cCbmPU@TuUM@@@AAADP@@ Final step perfromed at Pharmaron giving only a 25% ee Pharmaron PH-VIN-0027 Racemic mixture 0.193 1 0.0171 g 99 E06645-045A1 2020-02-20 0.598 NaN :UvzvtzxRjwWqAzUwQlYAPcb89MdnB9g7xL6BmiHIluDOwYD9L0_i4xB80YV7eHdB3k0XkZt34PN!GFBW0F0 NI17-0147 elV\BH@LGDhD@n`@cIIBhiDkdihheDidddcKAiodPXUjBhBfjih@@@@`b`@ In progress - Yunlong 1.13 1 NaN =ntztuiw_qAezo8l2AHcWc9MWVh0g7l244mg2GlF0OoW6160_aZpBN0WV5eFcB1V0V04d0V@8!G!W8FF NI17-0146 elVRJD@LGDchDC@f`@aFPrRPjJIKEJZIJJZIIKFPsRrxGzEZ`hHiji`@@B`HHh@@ Tested - MS CRC ChemPartner 0.084380.07776 0.0033 13.83 1.06 14.18 90.8 62.73 1 *%Stability at 6hr 96.23**%Stability at 6hr 27.17 261.11 70 77 85.31 86.17 0.2 13.86 53.29** 66.67* 175.955 :UvzvtzvRjwWqQvUo8lXAHcf8AMWVC0g7p244mg2GlF0OoY6960_a6pB80WV5eFcB1V0V04d34@8!G!W8F0 NI17-0145 eb^RBD@LCOLhDHn`@cFPrRPjJIKYYSQIQSQIIXrFZVOP`hkTEAESUS@@@E@PIP@ Tested - MS CRC ChemPartner 0.23260.1948 0.0189 20.05 1.74 11 63.9 1 264.29 59.91 74.6 74.92 0.284 79.95 0.18 10.81 164.095 =ntztuiw_qAezo8lXAHcWc9MWVh0g7l244mg2GlF0OoW6960_aZpB80WV5eFcB1V0V04d2Z@8!G!W8F0 NI17-0144 elV\JD@LGDhDC@f`@aFPrRPjJIKEJZIJJZIIKFPsRrxGzEZ`hHiji`@@B`HHh@@ Tested - MS CRC ChemPartner 0.01380.016 0.0011 1.84 10.64 3.09 7.11 90.23 1 *Unstable in Mouse Plasma**60.18 % stability at 6 hr 3.97 10.57 72.4 60.8 0.060708319240863 98.16 1.74 18.41 130.14 10.65 *88.92 80.16 80.47 17.29 17.22 **84.88 5.54 :UvzvOzxJjwWLAzUwQlY9PcaB8M9nC9ZMtL6BXiHQkv8tiXD1L0_i4Sg80WWMkHdc7tVXHZt14H!FG18W8F0 NI17-0143 elV\BD@LGDhD@a`@aFPrRPjJQJyJZJJJYZKKXrrikYxFEZ`j@ijhF@@BHHHj@@ Shipped to Dundee 9/20 ChemPartner >1 #DIV/0! 69.07 1 30.93 NaN :Uvzv;OyxvyteUxPnyAHhdASUgVC5iblL97HgVGrRZOoWyda0za4p4c0W_1@Vc5VV524Zl24@N!F80W8FV NI17-0142 edR\BL@LKHhDOJ`@a`HadLddJbdRnTtRTTtRRVNaawspJuSUUMUL@@@RD@T@@ In progress - Chaoyang ChemPartner 0.961 1 66 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44Hg2GlF0OoWD960_a4pBN0WV1eFcB1V020Zt24@8!G!W8FF NI17-0141 elZRBD@LFGDhD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ Shipped to Dundee 10/11 ChemPartner 0.0274 #DIV/0! 1 19.74 4.98 65.98 61.83 2.91 14.48 1236.55 1.12 374.69 135.71 3.70 10.21 19.74 :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44Hg2GlF0OoWD960_a4pBN0WV1eFcB1V020Zt24@820G!W8FF NI17-0140 elZRBD@LMGDhD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ Shipped to Dundee 10/11 ChemPartner 0.0462 #DIV/0! 1 0.47 367.21 3.77 274.12 72.48 5.06 19.12 0.47 :UvzvtzxRjwWqAvUwQl3APcb89MdlC9gMxL6BmiHIlv8OwYD1L0_i4xBN0YVMuHdB3k0XFot10Q8!GF0W8FF NI17-0139 eb^RBD@LGDehD@n`@cFPrRPjJQJyJZJIQKQIIXfVMSOP`hkTEPEMUSP@@D@PQD@@ Tested - MS Single point screen ChemPartner #DIV/0! 91.5 1 >10 8.5 NaN :UvzvtzxRjwWqAvUwQl3APcb89MdlC9gMxL6BmiHIlv8OwYD1L0_i4xBN0YVMuHdB3k0XFot10Q8!GF0W8FF NI17-0138 eb^RBD@LGDkhD@n`@cFPrRPjJQJyJZJIQKQIIXfVMSOP`hkTEPEMUSP@@D@PQD@@ Tested - MS Single point screen ChemPartner #DIV/0! 82.4 1 9.233 17.6 NaN :UvzvtzxRjwWqAvUwQl2QPcbB9MdlC9gMxq74miHQlG8OwYD3M0_i4xBNVYWKeHdB1tVXFot10Q83JG10W8FF NI17-0136 elVRBD@LGDnhD@a`@aFPrRPjJQJyJZJIJIZKKXrpikYxFEZ`j@ijjF@@B@HHb@@ Shipped to Dundee 10/11 ChemPartner >1 #DIV/0! 94.2 1 5.8 NaN :UvzvtzxRjwWqAvUwQl2QPcbB9MdlC9gMxq74miHQlG8OwYD3M0_i4xBNVYWKeHdB1tVXFot10Q81JG10W8FF NI17-0135 elVRBD@LGDmhD@a`@aFPrRPjJQJyJZJIJIZKKXrpikYxFEZ`j@ijjF@@B@HHb@@ In progress - Chaoyang ChemPartner #DIV/0! 1 >10 9 NaN :UvzvtzxRjwWqAvUwQl2QPcbB9MdlC9gMxq74miHQlG8OwYD3M0_i4xBNVYWKeHdB1tVXFot10Q81JG10W8FF NI17-0134 elVRBD@LGDghD@a`@aFPrRPjJQJyJZJIJIZKKXrpikYxFEZ`j@ijjF@@B@HHb@@ In progress - Yunlong ChemPartner #DIV/0! 112 1 >10 0 NaN :UvzvtzxRjwWqAvUwQl2QPcbB9MdlC9gMxq74miHQlG8OwYD3M0_i4xBNVYWKeHdB1tVXFot10Q81JG10W8FF NI17-0133 elVRBD@LGDehD@a`@aFPrRPjJQJyJZJIJIZKKXrpikYxFEZ`j@ijjF@@B@HHb@@ In progress - Yunlong ChemPartner >1 #DIV/0! 1 3 NaN :UvzvtzxRjwWqAzUwQlXQPcbB9MdnC9gMxq74miHQlG8OwYDAM0_i4xg8VYWKfHdB1tVXFot34Q81JG10W8F0 NI17-0132 elV\BD@LGDhD@a`@aFPrRPjJQJyJZJIJIZKKXrpikYxFEZ`j@ijjF@@B@HHb@@ Tested - MS Single point screen ChemPartner #DIV/0! 94.9 1 >10 5.1 NaN :UvzvtzxRjwWqAvUo9lYAPcb89MWkC9g7x264miHIlm8OwY69L0_i4xB80YV5eHdB3k0VF4d34P8!G!W8F0 NI17-0131 elZ\BD@LC@hDGJ`@aFPrRPjIKYJZJIQJZYIKESRxGzEZ``JZjf`@@B@`|`@ Tested - MS Single point screen ChemPartner #DIV/0! 93.8 1 >10 6.2 NaN :UvzvtzxRjwWqAvUo9lXAPcb89MWkC9g7p264miHIlF8OwY69L0_i4xB80WV5eHdB1k0VF4d34P8!G!W8F0 NI17-0130 edR\BD@LC@hDGJ`@bFPrRPjIKYJZJISSQIIXjZG_O@kTDASUTp@@A@P^P@ Tested - MS CRC ChemPartner Single stereoisomer 2.012.011.3661.15 0.3837 79 1 21 NaN :UvzvtzxRjwWqAvUo9lXAPcb89MWkC9g7p264miHIlF8OwY69L0_i4xB80WV5eHdB1k0VF4d34P8!G!W8F0 NI17-0130 edR\BD@LC@hDGJ`@bFPrRPjIKYJZJISSQIIXjZG_O@kTDASUTp@@A@P^P@ Pharmaron PH-VIN-0040 Single stereoisomer 1.783 79 2 0.0447 g 99 E06478-069A1 20191230 6.352 21 NaN :UvzvtzxRjwWqAvUwQl3APcb89MdlC9gMxL6BmiHIlv8OwYD1L0_i4xBN0YVMuHdB3k0XFot10Q8!GF0W8FF NI17-0129 eb^RBD@LGDghD@n`@cFPrRPjJQJyJZJIQKQIIXfVMSOP`hkTEPEMUSP@@D@PQD@@ Tested - MS CRC ChemPartner Tentative assignment (NOESY) 4.4691.504 1.4825 53.38 1 3.777 46.62 NaN :UvzvtzxRjwWqAzUw9lYAPcb89MdnC9gMx26BmiHIlv8OwY69L0_i4xg80YVMuHdB3k0VFJd34Q8!GF8W8F0 NI17-0128 edZ\BD@LC@hDGJ`@bFPrRPjIKYJZJIQKQIIXjZE]G_O@kTDASUTt@@A@DGa@@ Tested - MS CRC ChemPartner Racemic mixture 4.6515.5964.8243.891 0.6059 88 1 12 NaN :UvzntztNiyWqAiUwPtXALcl89rdYB0wMlU4Bmg2GlG0SqWD962_a4pi84WV5eGcR9V0Y0ot24A8!lFBW0F0 NI17-0127 eb^\BH@LGDhD@a`@cIIBhiDkdiiDdhhXddlYYtm|cCbmPU@TuUS@@@AAADP@@ Tested - MS Single point screen ChemPartner Racemic mixture >1 #DIV/0! 83 1 17 NaN :UvzntztNiyWqAiUwPtXALcl89rdYB0wMlU4Bmg2GlG0SqWD962_a4pi84WV5eGcR9V0Y0ot24A8!lFBW0F0 NI17-0126 edZ\BH@LC@hDGF`@cIIBhdmdiiDdhhXddliiTM\C}BmPPEMUTp@@@PP^D@@ Tested - MS Single point screen ChemPartner Racemic mixture >1 #DIV/0! 106 1 -6 NaN =rtztuiw_qEeUoP_XEHcWc9MWVhVZ7lJZ4ms2GlF0QkWE960_aZKB01W05eFVB1!X0Zx2V@84VG!W8F0 NI17-0123 edRTBD@LGHD@d`@bFPrRPjJQJyJZIIQQIIXfVG_O@kTEPEMUP@@A@PQP@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 92 1 8 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mc2GlF0OoWD960_a4KB!WV5eFVB1V0X0Zt24@8!G!W8F0 NI17-0122 edR\LD@LGDhD@`@bFPrRPjJQJyJZIIQQIIXfVG_O@kTEPEMUP@@A@PQP@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 98 1 2 NaN =ntvtuiF_q3@mkmlXAHVVV13G0d2g4lL04Hg2lGF0Oo0B9604aok880G!2Fc8#20Vt2a@8!G!W8F0 NI17-0119 edRTBD@LHhDGJ`@bFPrRPjJQJyIQIQSQIIXfVG_O@kTEPEUTp@@A@PAP@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 89 1 11 NaN :UvzntvtNiFWq3@HkHlXAHVV013W090g5lL04mg2GGF0Oo0B9604a4k8801V42FcB#X0Zt24@8!G!W8F0 NI17-0118 edR\LD@LGHhDJ`@bFPrRPjJQJyIQIQSQIIXfVG_O@kTEPEUTp@@A@PAP@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 86.5 1 13.5 NaN :UvzntztNiwWqAeUoPlXAHuW89MWVC0g7lL44mg0GlF0OpWD96V_a4pB80WV5e0c41V260Zt24@8!J!W8F0 NI17-0117 elZ\BD@LKDhD@f`@aFPrRPjJQJsZZIJJZIIKDqrxGzEZ`jBIji`@@B@`b`@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 77 1 23 NaN ^y;juUry_fEHhpfdU_gRWbjlJq7uwPlnFVOoWU948ba4KB8FWV_emZB1V4XGZtH4@8!G22W0F0 NI17-0116 elZ\FH@LGDhD@fndP@cIIBhiDkdihdhideEecKCohTUjBhBfjfBBbhJBJ@@ Tested - MS Single point screen ChemPartner #DIV/0! 74 1 3.048 26 NaN ;vzv:xwixYrAuUrTWYAHh_89M_VR1_7lJ67ugHGnFVOoWD940_a4KB80WV5emVB1V4XFZt24@8!G02W0F0 NI17-0115 fgqR@LNSA@V}@DYIHUEHe\eMDeELecVO]Z`j@iji``@aF@@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 89 1 11 NaN ?vxTiIlqbPmnrtrEHVmF1ArFt0g5lLV5Xc2GGk9Qw2B9686aZs8@0F042FcB!4X0Zt25@80VG!Y8G0 NI17-0114 ebV\BD@LGLhDHn`@cFPrRPjJQJyISQIQSQIIXfVOP`hkTEPEUUS@@@D@`EDh@@ Tested - MS CRC ChemPartner 3.354.239 0.4445 77.9 1 22.1 NaN ?vxTiIlqbPmnrtrEHVmF1ArFt0g5lLV5Xc2GGk9Qw2B9686aZs8@0F042FcB!4X0Zt25@80VG!Y8G0 NI17-0113 ebV\BD@LGLhDHn`@cFPrRPjJQJyISQIQSQIIXfVOP`hkTEPEUUS@@@D@`Ddh@@ Tested - MS CRC ChemPartner 1.2211.274 0.0265 44 10.19 2.67 33.2 1 23.25 5.55 69.87 81.85 2.882 56 3.60 20.02 28.225 :UvzvtztRiyWqAuUoQtmAHcbR9rYkC1w7lU64miHGlF9xybD962_a4xDA4WV5eHcw9o0YHZtD5@880l!WNF0 NI17-0112 eb^\BD@LGDhD@n`@cFPrRPjJQJyJZQKQSQIIXfVYEOP`hkTEPEMUS@@@DPHQSI@@ On hold - 0111 not active >1 #DIV/0! 1 100 NaN :UvzvtztRiyWqAuUoQtmAHcbR9rYkC1w7lU64miHGlF9xybD962_a4xDA4WV5eHcw9o0YHZtD5@880l!WNF0 NI17-0111 eb^\BD@LGDhD@n`@cFPrRPjJQJyJZQKQSQIIXfVYEOP`hkTEPEMUS@@@DPHQKJ@@ Tested - MS Single point screen ChemPartner racemic mixture >1 #DIV/0! 104 1 -4 NaN :UvzvtztRiyWqAuUoQtmAHcbR9rYkC1w7lU64miHGlF9xybD962_a4xDA4WV5eHcw9o0YHZtD5@880l!WNF0 NI17-0110 eb^\BD@LGDhD@n`@cFPrRPjJQJyJZQKQSQIIXfVYEOP`hkTEPEMUS@@@DPHQSJ@@ On hold - 0109 not active >1 #DIV/0! 1 100 NaN :UvzvtztRiyWqAuUoQtmAHcbR9rYkC1w7lU64miHGlF9xybD962_a4xDA4WV5eHcw9o0YHZtD5@880l!WNF0 NI17-0109 eb^\BD@LGDhD@n`@cFPrRPjJQJyJZQKQSQIIXfVYEOP`hkTEPEMUS@@@DPHQKI@@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 85.3 1 14.7 NaN :UvzvtzvRjwWqAvUoPlXAIcbBAMWVC0g7pLD4mg2MlF0OofDOL0pa6xB80Wm5eHcB1VVX0_t34@91FG!W8F0 NI17-0108 ebV\BD@LGLhDHn`@cFPrRPjJQJyQPqIQSQIIXfVOP`hkTEPESUS@@@DA@e@@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 99 1 1 NaN :UvzvtzxRjwWqAvUoQlXAPcb89MWkC9g7pL64miHIlF8OwYD9L0_i4xB80WV5eHdB1k0XFZt34P8!G!W8F0 NI17-0107 ebV\BD@LGDhD@n`@cFPrRPjJQJyJZJISSQIIXfVOP`hkTEPEMUS@@@DAAE@@ Tested - MS CRC ChemPartner Single stereoisomer 0.05470.0524 0.0012 0 21.39 0.91 7.33 15.15 1.88 4.95 98.9 1.1 yes 1 4.34 0.77 31.12 56.11 0.926 100 4.47 3.43 5.835 :UvzvtzxRjwWqAvUoQlXAPcb89MWkC9g7pL64miHIlF8OwYD9L0_i4xB80WV5eHdB1k0XFZt34P8!G!W8F0 !B_y}bOybOrw_x@bGw}bK]}K^HHc|bGvHHa}g~HHa}`BHOymrH__x@`Bw_X`BmrwK_|`C~@K_}ms~@@ NI17-0107 ebV\BD@LGDhD@n`@cFPrRPjJQJyJZJISSQIIXfVOP`hkTEPEMUS@@@DAAE@@ Pharmaron PH-VIN-0039 Single stereoisomer 0.357 0 99.01 2 0.0306 g 98 E06478-068A1 20191230 *81.82% stability at 6 hr**49.19% stabiltiy at 6 hr 0.9261.099 100 **99.01 *97.56 NaN :UvzntztNiwWqAeUoPl2AHcW89MWVC0g7lL44mg2GlF0OoWD160_a4pBN0WV5eFcB1V0X0Zt!@8!G!W8FF NI17-0106 elZRBD@LGDchD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ Tested - MS CRC ChemPartner Single StereoisomerIn Mitobridge Patent 0.01430.0114 0.0014 4.4 4.71 8.09 34.95 24.63 6.32 2.16 1 1.78 45.39 67.42 61.11 95.6 0.43 19.48 62.82 1.17 11.93 10.15 87.76 106.15 33.18333 :UvzntztNiwWqAeUoPl2AHcW89MWVC0g7lL44mg2GlF0OoWD160_a4pBN0WV5eFcB1V0X0Zt!@8!G!W8FF NI17-0105 elZRBD@LGDahD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ Tested - MS CRC ChemPartner In Mitobridge Patent 0.00950.0138 0.0022 0.1 27.36 1.51 39.55 96.294.20 3.8 yes 1 *Unstable in Mouse Plasma**9.2% Stability at 6hr 60.27 1.49 69.57 81.41 0.0730.052 99.9 11.95 17.77 988.94 1.40 *27.53 373.05 221.31 3.72 6.26 **66.33 8.69 14.85 1.71 92.95 96.49 49.91 :UvzntztNiwWqAeUoPlXAHc189MWVB0g7lL44mg2GlF0OoWD840_a4pB80WV5eFVB1V0X0Zt24@8!G!W0F0 NI17-0104 fkopR@LNSA@V`BLddJbdRnRfbRbaRM[YujBhBfjf@@HQ`@ Tested - MS Single point screen ChemPartner In Mitobridge Patent >1 #DIV/0! 85.4 1 14.6 NaN =v:xzyzpqfuUrglYAHclc9U_cSVgEl2J5mg2llF0OoW6968ba4pB8FWV5eFcB1V4V14d24@@!G!W8F0 NI17-0103 ejQ\JD@L@bhDODa`@`fPrRPjJIIK[JZIJJZIIKGQrssyFGEZ`hJJfjf@@@H``r`@ Tested - MS CRC ChemPartner 0.01480.0438 0.0145 14.04 3.36 1.21 95.5 4.5 yes 1 0.031 0.100 1.21 :Uvzv;S:tyvvUrBnbfuct8AU_VSNgEp245mg2GlF0OoW6968baBpBDFWX5eFcB1V4V14d24@8!GV0W8F0 NI17-0102 efYRBD@LO@jhDLi`@bfPrRPjJIIKYKSQIQSQIIXzNV^@xhdkTEAQUMUL@@@QA@U@@ Tested - MS CRC ChemPartner 0.09990.0962 0.0018 92.3 7.7 yes 1 0.096 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVB0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!W0F0 NI17-0101 edR\BH@LGDhD@f`@cIIBhiDkdihdhihddlYY\C}BmPU@TuTp@@@AAE@@ Tested - MS CRC ChemPartner Cmpd 35 BMCL 2018 0.0050.0119 0.0035 0 Cmpd 35 BMCL 1 0.060 100 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 NI17-0100 ejQ\BD@L@bhDDa`@`fPrRPjJIIK[JZIJJZIIKGQrssyFGEZ`@@Bfjf@@@H@`r`@ Tested - MS CRC ChemPartner Single enantiomer 0.10850.0865 0.011 yes 1 NaN :Uvzv:xOyzlqfeUpBtXALcl89U_VS0gEl244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V1Bd24@8!G!W8F0 NI17-0099 ejQ\BD@L@bhDDa`@`fPrRPjJIIK[JZIJJZIIKGQrssyFGEZ`hJJfjf@@@H``r`@ Tested - MS CRC ChemPartner Single enantiomer 0.06490.0825 0.0088 yes 1 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 NI17-0098 e`T\BD@LMOHDKL`@czPrRPjYKISQIQSQIIXrJKWGOKT@EMUL@@@PDCd@@ Tested - MS CRC ChemPartner Single enantiomer 0.09990.0816 0.0092 yes 1 0.215 NaN =rtztsiw_qAeUoPpXEHcW89MWVC0g7lL44mg2GlF0OoWE960_a4pB80WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0097 elZTJD@GDhDL@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ synthesis paused ChemPartner >1 #DIV/0! 1 NaN :UvzntztNiwWqAeUoPlXAH8W89MWVC0g7lL44mZ2GlF0FoW6960_a4pB80WV5eFcB1V0X0Z12488!G!V8F0 NI17-0096 edR\LH@IGKaKC`ICHhdlieEEeEDdebieIPpuLLm@AMTu@@@DuTA@h`@ Tested - MS Single point screen ChemPartner >1 #DIV/0! 87.7 1 12.3 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0095 elZ\BD@LGDhD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`bP@ Pharmaron PH-VIN-0002 Single stereoisomer >10 86.7 2 0.0526 g 99 E06478-006A1 20191111 6.326 13.3 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0095 elZ\BD@LGDhD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`bP@ Tested - MS Single point screen ChemPartner NI-A-010131 Single enantiomer R 10.0905 0.9655 0 1 100 >10 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0094 elZ\BD@LGDhD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ Tested - MS CRC ChemPartner NI-A-010130 Single enantiomer SCmpd 39 BCMS 2018 0.0340.03370.06090.0510.04740.0330.04380.0434 0.01566 0 23.53 1.05 4.6 61.47 31.4 20.14 98.7 1.3 1 0.0390.0320.032 100 4.6 :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0094 elZ\BD@LGDhD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ Pharmaron PH-VIN-0001 Single enantiomer SCmpd 39 BCMS 2018 0.03360.0640.0390.020810.0546150.0515950.043365 0.00726 ND 2 0.0468 g 98 E06478-003A1 20191111 Unstable in Mouse Plasma*2% BSA Added**47.07 % Sability at 6 hr 7.03 1.62 1.93* 38.49 73.91* 52.11 70.37* 0.0090.0050.0070.0070.0060.0080.0080.0080.0080.0090.0090.0080.0080.0090.0090.0069001950.0074883230.0062739650.009 0.005 0.007 0.0038373330.0084600690.004 0.0090.008 99.99 3.34 5.19* 5.41 10.03* N.A. **92.22 0.025 7.03 NI17-0094 2.1 IC50 run at Pharmaron on fresh powder, July 28 0.005 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 NI17-0093 elZ\BD@LGDhD@f`@aFPrRPjJIKEJZIJJZIIKGRrxGzEZ`hHiji`@@B@PhTT@@ Tested - MS Single point screen ChemPartner NI-A-010129 Single enantiomer 0.01990.024 0.0021 0 yes 1 100 NaN :UvzvtztRiyWqAuUoOtmAHcnN9rYkC0g7l244mg2GlF9Owb6960_a4xB80WV5eFcB1V0V04d25@8!l!WNF0 NI17-0092 eb^\BD@LOLhDHn`@cFPrRPjJIJZiSQIQSQIIXzNFVOP`hkTEAQSUS@@@DPHTIJ@@ Tested - MS Single point screen ChemPartner NI-A-010128 Single enantiomer 0.02740.0255 0.0009 0 yes 1 100 NaN :UvzvtztRiwWqfuUoAlmAHcY89MYkC0g7l644mg2GlF9OwYD962_a4xB82WV5eFcB1V0V04t25@8!G!W8F0 NI17-0091 ej^\BJ@L@bhDDa`@`rPldGI@fPrRPjJIJSMJZIJJZIIKGSsyFGEZ`hJbfjf@@@HABbYP@ Tested - MS Single point screen ChemPartner NI-A-010127 Single enantiomer 0.06260.0287 0.017 20.7 yes 1 0.365 79.3 NaN :UvzvtztRiwWqfuUoQlmAHcY89MYkC0g7lM44mg2GlF9OwYD962_a4xB82WV5eFcB1V0X0Zt25@8!G!W8F0 NI17-0087 efQ\BJ@LHjhDLi`@brP\dOIBfPrRPjJQIREiSQIQSQIIXfA@xhdkTEPUEMUL@@@PDAT@@ Tested - MS CRC ChemPartner NI-A-010123 Single enantiomer 0.00640.0155 0.0046 0 99.17144591 yes 1 * Compound is highly unstable in mouse plasma.** 2% BSA added 0.71 49.55 69.01291888 0.027 100 **5.13 3.67 ∞* 0.00* N.A.* 2181.77 794.91 0.64 1.74 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lM44mg2GlF0OoWD962_a4pB80WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0082 ebV\BD@LOLhDHn`@cFPrRPjJQIDiSQIQSQIIXfNOP`hkTEPQSUS@@@DA@e@@ Tested - MS CRC ChemPartner NI-A-010118 Single enantiomer 0.00790.0184 0.0053 3.6 yes 1 96.4 NaN :UvzvtztRiwWqfuUo@lmAHcY89MWVC0g7l644mg2GlF0OoYD962_a4xB82WV5eFcB1V0V04t24@8!G!W8F0 NI17-0078 ebV\BJ@LOLhDHn`@cRPLdKICFPrRPjIIRIiSQIQSQIIXjNOP`hkTDEQSUS@@@DA@e@@ Tested - MS CRC ChemPartner NI-A-010114 Single enantiomer 0.00880.027 0.0091 6.5 yes 1 0.388 93.5 NaN :Uvzv;S:vyfvUrTOLfUdbEEU_VSBs3xTD7mh2M_FVCafTGH0oa6pD84Ym5cHcB9WkX0ht10211FG!W8F0 NI17-0075 e`T\BD@LGBhDHa`@czPrRPjJQJyQQZIFZIKFVUMWOKTEPESUTp@QDBQ@@ Tested - MS Single point screen ChemPartner NI-A-010111 racemic mixture >1 #DIV/0! 98.2 1 >10 1.8 NaN :Uvzv;S:vyvvUrPQHfQcjCAU_VC8sAxTD7mh2M_F0CafTGH0oa6pD8JYm5cHeB9WZX1_t90211FGV0W8F0 NI17-0074 eoh\BD@LGBhDHn`@azPrRPjJQJyQQZ[SQIXrsJhzyZ`j@jZjX@HbAH`@ Tested - MS Single point screen ChemPartner NI-A-010110 racemic mixture >1 #DIV/0! 100.6 1 >10 -0.6 NaN :Uvzv:xNizlqfeUpTO6ALdp89z_VS0s3lU44mg2GWFVCaWD126Za4pD84WV5cFcR9V0Y0gt!2#l!W8F0 NI17-0073 e`T\BD@LGDhD@a`@czPrRPjJQJyJZQIJVIKFVM]WOKTEPEMUTp@Q@@@ Tested - MS Single point screen ChemPartner NI-A-010109 achiral >1 #DIV/0! 109.7 10 1 -9.7 NaN :UvzvtzxRjwWqAzUwQlYAPcb89MdnC9gMxL6BmiHIlv8OwYD9L0_i4xg80YVMuHdB3k0XFot34Q8!GF8W8F0 NI17-0072 eb^\BD@LGDhD@n`@cFPrRPjJQJyJZJIQKQIIXfVMSOP`hkTEPEMUSP@@D@PQD@@ Tested - MS CRC ChemPartner NI-A-010108 racemic mixture 0.48550.4748 0.0053 16.1 24.25 0.92 15.9 10.78 11.47 3.44 98.8 1.2 yes 1 14.07 0.61 51.57 72.95 1.8242.7932.548 83.9 9.42 5.73 >10 14.985 :Uvzvv:RjwtqfzUxPlqAQcbCAUhYC8gMxLDBmg2Mpt0OofDOL0pa6xg84YmMuIdB1WVX0_t34A91FGF8W8F0 NI17-0071 eb^\BD@LGBhDHm`@cFPrRPjJQJyQQZJKIQFYKFVUMKWPhkTEPESUA@p@DPPID@@ Tested - MS Single point screen ChemPartner NI-A-010107 racemic mixture #DIV/0! 101.5 1 >10>10 -1.5 NaN :UvzvtzvRjwWqAzUwPlXQIcbBAMdYC0gMxqE4mg2UlG0OofDQM0pa6pg8VYn5fIcBGcVX0_t34A91JG10W8F0 NI17-0070 elV\BD@LGAhDLm`@aFPrRPjJQJyQQQQYGSQIXrpikjXFEZ`j@jAbHf@BHHBj@@ Tested - MS Single point screen ChemPartner NI-A-010106 racemic mixture #DIV/0! 88.5 yes 1 >10 11.5 NaN :UvzntztNiyWqAiUwPlXAHcl89rdYC0g7lM4Bmg2GlF0OoWD962_a4pg80WV5eFcR1V0Y0Zt24A8!l08W8F0 NI17-0069 eb^\BD@LGDhD@a`@cFPrRPjJQJyJZQIJIZIIGFVM]O_PhkTEPEMUTp@@D@@@@ Tested - MS Single point screen ChemPartner NI-A-010105 achiral 0.49240.3356 0.0784 39.8 2.1 yes 1 0.40 0.70 51.53 90.98 0.873 60.2 8.60 6.05 1.25 :UvzvtztNiwWqveUoQlmAnBWB9MYVCFg7lL44na2GlF1koWDO62_b4pB88WV5eFcB__0X2ZG6489F0G!V8F0 NI17-0066 ej^\DB@IGCaK@ICzPAdHYCHhdlieEEeEDdebheHiJFFiaeh@Ijfh@@@jjj`HED@@ Tested - MS CRC ChemPartner NI-A-010102 6.48415.424 4.47 65.2 yes 1 >10 34.8 NaN :UvzntztNiwWqAeUwPlXAHcW8OMWVC0g7lL44mg2OlF4OoW6960_a4pB80WV5eFcB1X0W04d2488!G!V8F0 NI17-0064 elZ\LD@DGDh@f`@aFPrRSJZQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`b`@ Tested - MS Single point screen ChemPartner NI-A-010100 >1 #DIV/0! 87.2 yes 1 12.8 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0ZO24@8!G!W8F0 NI17-0061 edR\LD@DKHhOJ`@bFPrRYQRIWISQIQSQIIXzFG_O@mPU@TuTp@@A@PAP@ Tested - MS Single point screen ChemPartner NI-A-010097 0.40360.4134 0.0049 39.1 26.85 0.83 21.2 21.64 20.84 18.35 97.4 2.6 yes 1 38.74 0.99 59.67 84.45 60.9 10.18 10.05 29.97 :UvzvtztRiyWqAuUoOtmAHcnN9rYkC0g7l244mg2GlF9Owb6960_a4xB80WV5eFcB1V0V04d25@8!l!WNF0 NI17-0060 eb^\BD@LOLhDHn`@cFPrRPjJIJZiSQIQSQIIXzNFVOP`hkTEAQSUS@@@DPHTQJ@@ Tested - MS CRC ChemPartner NI-A-010126 Single Stereoisomer 0.00690.0132 0.0031 3.2 yes 1 96.8 NaN :UvzvtztRiwWqfuUoAlmAHcY89MYkC0g7l644mg2GlF9OwYD962_a4xB82WV5eFcB1V0V04t25@8!G!W8F0 NI17-0059 ej^\BJ@L@bhDDa`@`rPldGI@fPrRPjJIJSMJZIJJZIIKGSsyFGEZ`hJbfjf@@@HABaYP@ Tested - MS CRC ChemPartner NI-A-010125 0.00390.0224 0.0093 0 98.03680623 yes 1 * 2% BSA added 1.92 1.22 56.32 65.95802189 0.058 100 *5.01 6.12 915.66 1.51 92.1 384.19 530.46 3.61 2.61 1.92 :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 NI17-0058 elZ\BD@LGDhD@f`@aFPrRPjJIKEJZIJJZIIKGRrxGzEZ`hHiji`@@B@PhdT@@ Tested - MS CRC ChemPartner NI-A-010124 0.00880.0153 0.0032 0 yes 1 100 NaN :UvzvtzvRiyWqQuUoPtXAHcf89rWVC0g7lM44mg2GlF0OoYD962_a6pB@0WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0057 ebQ\BD@LOLhDHn`@cFPrRPjJQIDiSQIQSQIIXrVJVFNOP`hkTEPQSUS@@@EPDBT@@ PH-VIN-0051 Single stereoisomer 0.142 98.84 2 0.0498 g 99 E06639-003A1 20200108 * 2% BSA added 0.32 1.39 63.37 74.95956517 0.084 *3.76 5.22 702.87 1.97 219.73 162.09 6.31 8.55 0.158 0.67 4.82 6.13 1.27 91.28 90.86 99.28 101.04 98.93 32.48 N/A 0.04 0.495 :UvzvtzvRiyWqQuUoPtXAHcf89rWVC0g7lM44mg2GlF0OoYD962_a6pB@0WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0057 ebQ\BD@LOLhDHn`@cFPrRPjJQIDiSQIQSQIIXrVJVFNOP`hkTEPQSUS@@@EPDBT@@ Tested - MS CRC ChemPartner NI-A-010122 0.00860.0111 0.0012 6.2 13.76 1.32 6.31 37.5 34.2 10.9 99.387.50 0.7 yes 1 *Unstable in Mouse Plasma** 2% BSA added***43% stability at 6 hr 2.80 1.35 20.06 42.74 0.120 93.8 **1.73 2.34 336.13 4.12 >87.50* ***98.01 4.555 :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lM44mg2GlF0OoWD962_a4pB80WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0056 ebV\BL@LOLhDHn`@brPqdLddJbdRQJTtRTTtRRVIcctHJJuATDTuTp@@A@PIP@ Tested - MS CRC ChemPartner NI-A-010121 0.00840.0113 0.0014 0 97.34504132 yes 1 * Compound is highly unstable in mouse plasma.**If calculated CLint < 0, then T1/2, CLint and E were reported as "∞" , "0.00" and "0.0", respectively.*** 2% BSA added 8.02 1.21 65.26 71.22340646 0.021 100 ***5.47 6.62 ∞** 0.00** N.A.* 351.34 346.25 3.94 4.00 8.02 :UvzvtztRiwWqAuUoNlmAHcY89rWVC0g7l244mg2GlF0OoY6960_a4xB80WV5eFcB1V0V04d24@8!l!WNF0 NI17-0055 elV\BD@LGDhD@f`@aFPrRPjIIQUJZIJJZIIKERsPrxGzEZ``hiji`@@BHHHh@@ Tested - MS CRC ChemPartner NI-A-010120 0.01170.0187 0.0035 0.1 yes 1 99.9 NaN :UvzntztNiwWqAeUoPlXAHcW89rWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!WNF0 NI17-0054 elV\BD@LGDhD@f`@aFPrRPjJQJyJZIJJZIIKDRPrrxGzEZ`j@iji`@@B`HHh@@ Tested - MS CRC ChemPartner NI-A-010119 In Mitobridge Patent 0.00950.0091 0.0002 0.1 no 1 99.9 NaN :Uvzn:tNizlqAeUp8tXAHcl89M_VC0g7l244mg2GlF0OoW6964_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 NI17-0053 eb^\BD@LOLhDHn`@cFPrRPjJIIJiSQIQSQIIXzNFVOP`hkTEAQSUS@@@DPPIP@ Tested - MS CRC ChemPartner NI-A-010117 0.01190.0136 0.0009 0.1 yes 1 99.9 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 NI17-0052 elV\BD@LGDhD@f`@aFPrRPjJIKEJZIJJZIIKFPsRrxGzEZ`hHiji`@@B`HHh@@ Tested - MS CRC ChemPartner NI-A-010116 0.01030.0154 0.0026 6.9 yes 1 93.1 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!WNF0 NI17-0051 edZ\BD@LKHhDOJ`@bFPrRPjJIGISQIQSQIIXbRZFG_O@kTE@TuTp@@APD@T@@ Tested - MS CRC ChemPartner NI-A-010115 0.01440.0174 0.0015 0.1 yes 1 99.9 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 NI17-0050 edR\BD@LKHhDOJ`@bFPrRPjJIGISQIQSQIIXzFG_O@kTE@TuTp@@A@PAP@ Tested - MS CRC ChemPartner NI-A-010113 In Mitobridge Patent 0.01050.0151 0.0023 6.8 no 1 93.2 NaN :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 NI17-0049 eh\\BD@LC@hDGB`@`FPrRPjIKYJZIJJZIIKESSYz{yZ``JZjX@@@`HOH@@ Tested - MS CRC ChemPartner NI-A-010112 0.01290.0119 0.0005 0.1 17.74 2.15 5.95 18.3 8.33 5.03 97.1 2.9 yes 1 0.29 3.19 51.87 49.70 0.055 99.9 3.65 11.63 3.12 :UvzntztNiwWqAeUo8lXAHcW89MWVC0g7l244mg2GlF0OoW6960_a4pB80WV5eFcB1V0V04d24@8!G!W8F0 !BOXc|bN\}bMwg?Hc|Oa?gOX`}bCt~Gxc]b@H~@Hc]b@H~Gsx@bMwg?Hc|b@H~Gsx@bCvHwX`}bOrH?Cx_bCvH?@ NI17-0049 eh\\BD@LC@hDGB`@`FPrRPjIKYJZIJJZIIKESSYz{yZ``JZjX@@@`HOH@@ Viva V124142-000-001 2 0.13 g 100.0 V2529-032 2020-07-28 16:18:46 96.04 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lH44mg2GlF0OoWD960_a4pB80WV5eFcB1V0m04O24@8!G!V8F0 NI17-0048 edRTLD@KHhOJ`@bFPrRZIIRIiSQIQSQIIXbFG_O@mAATTuTp@@A@PAP@ Tested - MS CRC ChemPartner NI-A-010104 0.60520.78 0.0874 yes 1 1.867 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lH44mg2GlF0OoWD960_a4pB80WV5eFcB1V0m04t24@8!G!k8N0 NI17-0047 elZ\LD@DGDh@f`@aFPrRPqIJQMJZIJJZIIKFRrxGzEZBBhiji`@@B@`b`@ Tested - MS CRC ChemPartner NI-A-010101 >10>10 #DIV/0! yes 1 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lH44mg2GlF0OoWD960_a4pB80WV5eFcB1V0m04t24@8!G!V8F0 NI17-0046 elZTBD@GDhD@f`@aFPrRPqIJQMJZIJJZIIKFRrxGzEZBBhiji`@@B@`b`@ Tested - MS CRC ChemPartner NI-A-010098 0.23120.218 0.0066 9.21 1.73 0.52 6.58 7.25 7.86 yes 1 0.18 0.38 43.54 88.10 0.539281206 9.20 3.53 0.35 :UvzntztNiyWqAiUwPtXQHcW8OMdYC0wIly54mg2GlG6CqWDA30Za4py@4W_5fGcC9X1e0ot803804GN4W8FV NI17-0045 efYRBD@LGDghD@f`@bfPrRPjJQJyJZIJJZJIIK[FVGO@xhdkTEPEMUMHA@@QAAE@@ Tested - MS CRC ChemPartner NI-A-010096 In Mitobridge Patent 0.25170.2271 0.0123 1 NaN ;vzntztNiwWqAeUoPlXAHcW89MWVC2g7lL44mg2GlF0OoWD960_a4pB88WV5eFcB1V0X0ZtX4@8F0G!Y8G0 NI17-0044 ebV\JD@LGDhD@fdP@cFPrRPjJQJyJZIJJZIIKYFVW@PkTEPEMUL@@@TAAE@@ Tested - MS CRC ChemPartner NI-A-010095 In Mitobridge Patent 0.07010.0692 0.0005 1 NaN :UvzntztNiwWqAeUoPlXAHcW89MWVC0g7lL44mg2GlF0OoWD960_a4pB80WV5eFcB1V0X0Zt24@8!G!W8F0 NI17-0043 elZ\BD@LGDhD@f`@aFPrRPjJQJyJZIJJZIIKDrrxGzEZ`j@iji`@@B@`bH@@ Tested - MS CRC ChemPartner NI-A-010094 racemic mixtureCmpd 39 BMCL 2018 0.06380.04760.07620.07530.03140.03560.04170.0312 0.0177 Cmpd 39 BMCL 1 NaN :UvzfzUzO:QTPjCSRvHQ9vh8e__XN8TAwc50l1A11Ba_2W6GX026248kF2M3d42x92F4c408!F20VW0WVFk NI17-0014 fewy@@D\EHI^`RYYeUo~YVTxwfc{MjhJBc``b`XXh@@ Tested - MS CRC ChemPartner NI-A-010093 racemic mixtureMission Compound NA 0.82650.7124 0.0571 5.28 17.78 1.51 85.7 79.78 11.41 20.91 1 96.83 6.94 65.00 89.09 94.72 2.99 20.72 91.265 :UvzfzUzO:QTPjCSRvHQ9vh8e__XN8TAwc50l1A11Ba_2W6GX026248kF2M3d42x92F4c408!F20VW0WVFk NI17-0013 fewy@@D\ehI^`RYYeUo~YVTxwfc{MjhJBc``b`XXh@@ Tested - MS CRC ChemPartner NI-A-010092 racemic mixtureMission Compound NA 0.74640.9436 0.0986 1.66 1 98.34 NaN :UvzfzUzO:QTPjCSRvHQ9vh8e__XN8TAwc50l1A11Ba_2W6GX026248kF2M3d42x92F4c408!F20VW0WVFk NI17-0012 fewy@@D\dXI^`RYYeUo~YVTxwfc{MjhJBc``b`XXh@@ Tested - MS CRC ChemPartner NI-A-010091 racemic mixtureMission Compound NA 0.72640.7648 0.0192 9.11 1 90.89 NaN :Uvzv;S:QyujEUTvLv9vh8ep_aRBTAwx50n1f51Ra_2lDGX226258kF2M3d42xd2F5d4H8!F20WW0WcFk NI17-0011 fmoyB@F\MYuQtAHIMLnwN~sJpmAcvXuuSUTFAAAE@paP@ Tested - MS CRC ChemPartner NI-A-010090 racemic mixtureMission Compound <0.1 0.10880.1052 0.0018 -1.22 1 101.22 NaN :Uvzv;S:QyujEUTvLv9vh8ep_aRBTAwx50n1f51Ra_2lDGX226258kF2M3d42xd2F5d4H8!F20WW0WcFk NI17-0010 fmoyB@F\L{uQtAHIMLnwN~sJpmAcvXuuSUTFAAAE@paP@ Tested - MS CRC ChemPartner NI-A-010089 racemic mixtureMission Compound <0.1 0.10510.058 0.0236 -1.13 1 101.13 NaN :Uvzv;S:QyujEUTvLv9vh8ep_aRBTAwx50n1f51Ra_2lDGX226258kF2M3d42xd2F5d4H8!F20WW0WcFk NI17-0009 fmoyB@F\LxMQtAHIMLnwN~sJpmAcvXuuSUTFAAAE@paP@ Tested - MS CRC ChemPartner NI-A-010088 racemic mixtureMission Compound <0.1 0.07760.0545 0.0115 -1.11 21.35 1.11 0.62 48 45.2 <5 1 0.31 0.68 71.49 103.38 101.11 4.30 2.92 0.465 >U:pzxzyuvEbBrLEAUg@fK5VocUAx841I1941JVX3V7GXVX4X5DkFIJ1c4HV1!444!V!6V0V0VVFF NI17-0008 fi{h`@D\UDXJILlrjjZvjqoUzuTEAQXAGACB@@ Tested - MS CRC ChemPartner NI-A-010087 Mission Compound <0.1 0.05020.0547 0.0022 9.41 1 90.59 NaN >U:pzxzyuvEbBrLEAUg@fK5VocUAx841I1941JVX3V7GXVX4X5DkFIJ1c4HV1!444!V!6V0V0VVFF NI17-0007 fi{X`@D\UzHpTRYYeUU~umUc^kujhJBbpBNBFD@ Tested - MS CRC ChemPartner NI-A-010086 Mission Compound 10.0506 0.011 10.02 22.02 1.29 35.6 271.3 104.2 13.8 1 0.117 89.98 35.6 ;UvUzvM:WzyzQYY5MTEtJiqYAbosctdR@X4In671F9HD@_GH50TX8@LFIk!2HB0G040421Wk33V1V!V0F NI17-0006 figY@@FBuYHpISKOlk{JoQgA^CUmUUTFA@A]@bDq@@ Tested - MS CRC ChemPartner NI-A-010085 racemic mixtureMission Compound 0.0010.0169 0.0056 2.17 33.39 0.93 45.9 312.3 138.7 132.99 1 8.62 0.62 66.64 84.08 0.013 97.83 23.18 14.28 0.398 27.26 ;UvUzvM:WzyzQYY5MTEtJiqYAbosctdR@X4In671F9HD@_GH50TX8@LFIk!2HB0G040421Wk33V1V!V0F NI17-0005 figY@@FBuYhpYHheElhdmeDeCQgA^CUmUUTFA@A]@bBp`@ Tested - MS CRC ChemPartner NI-A-010084-1 from 19/20 racemic mixtureMission Compound 0.0010.0433 0.0076 8.32 1 91.68 NaN ;UvUzvM:WzyzQYY5MTEtJiqYAbosctdR@X4In671F9HD@_GH50TX8@LFIk!2HB0G040421Wk33V1V!V0F NI17-0004 figY@@FBuYhpYHheElhdmeDeCQgA^CUmUUTFA@A]@bDq@@ Tested - MS CRC ChemPartner NI-A-010084-0 from 19/20 racemic mixtureMission Compound 0.0010.0335 0.0004 3.23 1 96.77 NaN :Uvzv;OyzvyviEpTvyfqjrAhr_VJKjElMBqmgcFnkVSoWTB43l_DpB84WV5fgVJ9VF29gt24@8!g!W8F0 NI17-0003 ea]\BL@LHfhDBe`@afPydLddJbdTUbtNfbRbfbRRqeg`RTINMJuAT@ADuTpTEEPEAU@@ Tested - MS CRC ChemPartner NI-A-010083 In Mitobridge Patent >0.10 0.110.1591 0.0245 5.53 0.1 1 0.29 3.27 62.65 88.44 94.47 4.68 15.31 0.195 :Uvzv;OyzvyAiEpTtufqjMAdr_VJ5jElLBqmg8FnkVSoWTB41l_DpB84WV5fcVJ9VF28gt24@8!g!W0F0 NI17-0002 efY\BH@LHfhDBe`@cIIBhiEEXmCihdhihddmYxDeBScRmPU@@QMULEAQ@TET@@ Tested - MS CRC ChemPartner NI-A-010082 Compound 31 BMCL 2018 >0.12 0.09430.0756 0.0093 5.51 1 0.075 94.49 NaN :Uvzv;OyxfyAiEpTlufmj7Adr_VJ5j7lLBamg8FnFVOoWDB41l_DpB84WV5fcVJ1VF28Zt24@8!g!WFF0 NI17-0001 elV\BH@LHfhDBe`@cIIBhiEEXmCihdhihd[O@dgohTUjBh@BIji`h@H`j`@ Tested - MS CRC ChemPartner NI-A-010081 Compound 29 BMCL 2018 >10 1.7412.237 0.248 22.65 Compd 31 BMCL 1 >10 77.35 NaN ">